Protein name |
Sporulation killing factor (SKF) (Sporulation-killing factor SkfA) |
NCBI Accession ID |
AB006424.1 |
Organism |
Bacillus subtilis (strain 168) |
Left |
16922 |
Right |
17089 |
Strand |
+ |
Nucleotide Sequence |
ATGAAAAGAAACCAAAAAGAATGGGAATCTGTGAGTAAAAAAGGACTTATGAAGCCGGGAGGTACTTCGATTGTGAAAGCTGCTGGCTGCATGGGCTGTTGGGCCTCGAAGAGTATTGCTATGACACGTGTTTGTGCACTTCCGCATCCTGCTATGAGAGCTATTTAA |
Sequence |
MKRNQKEWESVSKKGLMKPGGTSIVKAAGCMGCWASKSIAMTRVCALPHPAMRAI |
Source of smORF |
Swiss-Prot |
Function |
Produces a 26-residue extracellular sporulation filling factor (SKF) that induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, providing a source of nutrients to support sporulation, and at the same time delaying commitment to the energetically expensive and irreversible onset of sporulation (Pubmed:12817086, Pubmed:20805502). Can also inhibit growth of other bacteria at high concentrations (Pubmed:11851812). Addition of SKF to solid cultures induces killing, but it is much less effective than SDP (AC O34344) (Pubmed:20805502). Has a role in protecting the secreted lipase LipA against proteolysis, either by modulating its folding or by acting as a protease inhibitor (Pubmed:15812018). {ECO:0000269|Pubmed:11851812, ECO:0000269|Pubmed:12817086, ECO:0000269|Pubmed:15812018, ECO:0000269|Pubmed:20805502}. |
Pubmed ID |
9384377
20805502
11851812
12817086
15812018
15687200
16816204
17720793
23282011
|
Domain |
CDD:275197 |
Functional Category |
Antimicrobial |
Uniprot ID |
O31422
|
ORF Length (Amino Acid) |
55 |