Result : O07779
| Protein Information |
| Information Type | Description |
|---|---|
| Protein name | Antitoxin VapB27 |
| NCBI Accession ID | AL123456.3 |
| Organism | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
| Left | 697564 |
| Right | 697800 |
| Strand | - |
| Nucleotide Sequence | ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTCCACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATGGCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA |
| Sequence | MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK |
| Source of smORF | Swiss-Prot |
| Function | Antitoxin component of a type II toxin-antitoxin (TA) system. Cognate toxin is VapC27. Upon expression in E.coli partially counteracts the ribonuclease activity of non-cognate toxins MazF6 and MazF9. {ECO:0000269|Pubmed:20876537}. |
| Pubmed ID | 9634230 20011113 20876537 21969609 |
| Domain | CDD:412624 |
| Functional Category | Antitoxin_type_2_and_DNA-binding |
| Uniprot ID | O07779 |
| ORF Length (Amino Acid) | 78 |
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| Conservation Analysis |
No. of Species: 10
| Sr.No. | Left Position | Right Position | Strand | NCBI Accession id | Species Name |
|---|---|---|---|---|---|
| 1 | 697564 | 697800 | - | NC_000962.3 | Mycobacterium tuberculosis H37Rv |
| 2 | 712700 | 712936 | - | NC_015848.1 | Mycobacterium canettii CIPT 140010059 |
| 3 | 3025106 | 3025342 | - | NC_007777.1 | Frankia casuarinae |
| 4 | 3898924 | 3899160 | + | NC_007777.1 | Frankia casuarinae |
| 5 | 204465 | 204701 | - | NC_008278.1 | Frankia alni ACN14a |
| 6 | 235283 | 235522 | - | NZ_CP025198.1 | Acidipropionibacterium virtanenii |
| 7 | 508138 | 508377 | - | NZ_AP022598.1 | Mycolicibacterium parafortuitum |
| 8 | 3972699 | 3972938 | - | NZ_AP022617.1 | Mycolicibacterium monacense |
| 9 | 1576164 | 1576403 | + | NZ_AP022616.1 | Mycolicibacterium phocaicum |
| 10 | 3983810 | 3984049 | - | NC_015635.1 | Microlunatus phosphovorus NM-1 |
| 11 | 3263352 | 3263591 | + | NZ_AP022615.1 | Mycobacterium heidelbergense |
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| Neighborhood Conservation Analysis |
* Arrows marked in Genome Diagram shows ORFs; Multiple PFAMs can be mapped to a single ORF.
* 'Small ORF' represents the entry/query analyzed.
* Image generated using 'gggenes'(R-Package).
Neighborhood Representative Chosen(Species): NC_000962.3
| Sr.No. | Domain | Co-occurrence Frequency | No. of species in which domain occurs with smORF | Median distance b/w smORF and domain bearing ORFs | Orientation relative to smORF | PFAM Information |
|---|---|---|---|---|---|---|
| 1 | PF01850.23 | 0.9 | 9 | -3 | same-strand | PIN domain |
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