Result : O06663
| Protein Information |
| Information Type | Description |
|---|---|
| Protein name | Antitoxin VapB |
| NCBI Accession ID | U82621.1 |
| Organism | Shigella flexneri |
| Left | 3605 |
| Right | 3832 |
| Strand | - |
| Nucleotide Sequence | ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAAACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGACACAGCGTCAGCACCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAAGAAAGGGAGTCATTCTGA |
| Sequence | METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHSVSTDFMDNREQPGMQERESF |
| Source of smORF | Swiss-Prot |
| Function | Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli neutralizes the effect of cognate toxin VapC. The VapB/VapC complex probably regulates transcription of its own promoter. {ECO:0000269|Pubmed:19400780, ECO:0000269|Pubmed:21502523}. |
| Pubmed ID | 9171415 12384590 19400780 21502523 22037005 |
| Domain | CDD:412624 |
| Functional Category | Antitoxin_type_2_and_DNA-binding |
| Uniprot ID | O06663 |
| ORF Length (Amino Acid) | 75 |
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| Conservation Analysis |
No. of Species: 89
| Sr.No. | Left Position | Right Position | Strand | NCBI Accession id | Species Name |
|---|---|---|---|---|---|
| 1 | 198515 | 198742 | - | NC_004851.1 | Shigella flexneri 2a str. 301 |
| 2 | 86967 | 87194 | - | NC_003277.2 | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
| 3 | 5716970 | 5717179 | + | NZ_CP070503.1 | Pseudomonas atacamensis |
| 4 | 41590 | 41817 | + | NZ_CP023707.1 | Edwardsiella tarda |
| 5 | 4970054 | 4970242 | - | NZ_CP040428.1 | Jejubacter calystegiae |
| 6 | 4667538 | 4667768 | + | NZ_CP011602.1 | Phytobacter ursingii |
| 7 | 3195560 | 3195787 | - | NC_003197.2 | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
| 8 | 3163992 | 3164174 | - | NZ_CP061511.1 | Mixta calida |
| 9 | 3881180 | 3881389 | - | NZ_CP014262.1 | Pseudomonas corrugata |
| 10 | 4753146 | 4753376 | - | NZ_CP011104.1 | Photorhabdus thracensis |
| 11 | 274763 | 274945 | + | NZ_CP045303.1 | Azotobacter salinestris |
| 12 | 5123726 | 5123956 | + | NZ_CP023525.1 | Cedecea neteri |
| 13 | 4802274 | 4802456 | - | NZ_CP063425.1 | Kosakonia pseudosacchari |
| 14 | 5527515 | 5527745 | + | NZ_CP048833.1 | Pseudomonas multiresinivorans |
| 15 | 3570169 | 3570378 | + | NZ_CP005960.1 | Pseudomonas mandelii JR-1 |
| 16 | 729583 | 729810 | + | NZ_AP018933.1 | Zymobacter palmae |
| 17 | 148404 | 148592 | - | NC_010694.1 | Erwinia tasmaniensis Et1/99 |
| 18 | 1058362 | 1058592 | - | NZ_CP067022.1 | Pseudomonas cannabina pv. alisalensis |
| 19 | 1150828 | 1151058 | - | NZ_CP068034.2 | Pseudomonas syringae |
| 20 | 4459938 | 4460168 | + | NZ_CP009533.1 | Pseudomonas rhizosphaerae |
| 21 | 1144032 | 1144262 | - | NC_004578.1 | Pseudomonas syringae pv. tomato str. DC3000 |
| 22 | 21307 | 21537 | - | NZ_CP015750.1 | Pectobacterium wasabiae CFBP 3304 |
| 23 | 2980757 | 2980987 | - | NZ_CP038498.1 | Pectobacterium punjabense |
| 24 | 1335509 | 1335742 | - | NZ_CP015881.1 | Ensifer adhaerens |
| 25 | 476636 | 476818 | - | NZ_CP022605.1 | [Ochrobactrum] quorumnocens |
| 26 | 5152114 | 5152296 | + | NZ_CP046621.1 | Pseudomonas alkylphenolica |
| 27 | 742120 | 742302 | - | NZ_CP048602.1 | Halomonas piezotolerans |
| 28 | 4229776 | 4229958 | + | NZ_CP009365.1 | Pseudomonas soli |
| 29 | 5185015 | 5185197 | + | NC_008027.1 | Pseudomonas entomophila L48 |
| 30 | 1898961 | 1899143 | - | NZ_CP064062.1 | Brucella anthropi |
| 31 | 1888572 | 1888802 | + | NZ_CP034938.1 | Pectobacterium odoriferum |
| 32 | 3005216 | 3005398 | + | NZ_CP031146.1 | Pseudomonas plecoglossicida |
| 33 | 134001 | 134231 | + | NZ_LR723673.1 | Pseudorhizobium flavum |
| 34 | 1733573 | 1733803 | - | NC_012880.1 | Musicola paradisiaca Ech703 |
| 35 | 4172528 | 4172758 | - | NC_012912.1 | Dickeya chrysanthemi Ech1591 |
| 36 | 2630723 | 2630953 | + | NZ_CP015749.1 | Pectobacterium parmentieri |
| 37 | 478046 | 478234 | - | NC_007484.1 | Nitrosococcus oceani ATCC 19707 |
| 38 | 107867 | 108055 | - | NZ_CP013125.1 | Pseudomonas mendocina S5.2 |
| 39 | 1866557 | 1866787 | + | NZ_CP007029.1 | Thioalkalivibrio paradoxus ARh 1 |
| 40 | 1883141 | 1883371 | - | NC_011761.1 | Acidithiobacillus ferrooxidans ATCC 23270 |
| 41 | 2914669 | 2914899 | - | NC_015942.1 | Acidithiobacillus ferrivorans SS3 |
| 42 | 5939895 | 5940125 | + | NZ_CP021425.1 | Oleiphilus messinensis |
| 43 | 3729232 | 3729462 | + | NZ_LT907988.1 | Orrella dioscoreae |
| 44 | 2537529 | 2537759 | + | NZ_AP017372.2 | Halorhodospira halochloris |
| 45 | 1620777 | 1621007 | - | NZ_CP004388.1 | Thalassospira xiamenensis M-5 = DSM 17429 |
| 46 | 2167330 | 2167560 | - | NZ_CP031555.1 | Thalassospira indica |
| 47 | 2116645 | 2116872 | - | NZ_CP065745.1 | Aeromonas allosaccharophila |
| 48 | 2096108 | 2096335 | - | NZ_CP065745.1 | Aeromonas allosaccharophila |
| 49 | 2395797 | 2395979 | - | NZ_LR215729.2 | Pseudomonas marincola |
| 50 | 3179298 | 3179531 | - | NZ_CP006877.1 | Rhizobium gallicum bv. gallicum R602sp |
| 51 | 2200281 | 2200505 | + | NZ_CP017482.1 | Pectobacterium polaris |
| 52 | 2703049 | 2703282 | - | NC_014664.1 | Rhodomicrobium vannielii ATCC 17100 |
| 53 | 2890233 | 2890424 | - | NC_020528.1 | Sinorhizobium meliloti 2011 |
| 54 | 1054240 | 1054422 | - | NC_015581.1 | Thiomicrospira cyclica ALM1 |
| 55 | 1195526 | 1195708 | - | NZ_CP007030.1 | Thiomicrospira aerophila AL3 |
| 56 | 3790200 | 3790433 | - | NZ_CP019948.1 | Methylocystis bryophila |
| 57 | 479471 | 479659 | + | NZ_CP045529.1 | Luteimicrobium xylanilyticum |
| 58 | 3994643 | 3994873 | + | NZ_CP041694.1 | Cellulosimicrobium cellulans |
| 59 | 804371 | 804562 | + | NZ_CP043929.1 | Methylomonas rhizoryzae |
| 60 | 56307 | 56528 | + | NZ_CP035129.1 | Kosakonia cowanii |
| 61 | 182857 | 183039 | - | NC_013530.1 | Xylanimonas cellulosilytica DSM 15894 |
| 62 | 2869494 | 2869679 | - | NC_011060.1 | Pelodictyon phaeoclathratiforme BU-1 |
| 63 | 43517 | 43741 | + | NZ_CP044115.1 | Roseomonas mucosa |
| 64 | 2073741 | 2073932 | - | NZ_CP028339.1 | Thauera aromatica K172 |
| 65 | 2696056 | 2696286 | + | NC_006512.1 | Idiomarina loihiensis L2TR |
| 66 | 282482 | 282706 | + | NZ_CP059564.1 | Alysiella filiformis |
| 67 | 719 | 943 | + | NZ_CP014682.1 | Kozakia baliensis |
| 68 | 1061226 | 1061450 | - | NZ_CP015164.1 | Acetobacter ascendens |
| 69 | 541853 | 542077 | - | NZ_CP043043.1 | Gluconobacter thailandicus |
| 70 | 121627 | 121851 | - | NZ_CP014690.1 | Gluconobacter albidus |
| 71 | 556787 | 556975 | - | NZ_CP004387.1 | Alcanivorax pacificus W11-5 |
| 72 | 3253819 | 3254010 | - | NC_010524.1 | Leptothrix cholodnii SP-6 |
| 73 | 1560773 | 1560997 | - | NZ_CP022374.1 | Acetobacter oryzifermentans |
| 74 | 2572815 | 2573039 | + | NC_016027.1 | Komagataeibacter medellinensis NBRC 3288 |
| 75 | 3816822 | 3817040 | + | NZ_CP053708.1 | Lichenicola cladoniae |
| 76 | 9887 | 10087 | + | NZ_CP038142.1 | Swingsia samuiensis |
| 77 | 3208757 | 3208981 | - | NZ_CP062147.1 | Komagataeibacter hansenii |
| 78 | 2405436 | 2405666 | + | NZ_CP014209.1 | Isoptericola dokdonensis DS-3 |
| 79 | 2442300 | 2442524 | - | NZ_CP042808.1 | Acetobacter oryzoeni |
| 80 | 1334367 | 1334567 | + | NZ_CP038141.1 | Swingsia samuiensis |
| 81 | 116585 | 116818 | - | NZ_CP028901.1 | Algicoccus marinus |
| 82 | 4314379 | 4314564 | - | NC_010995.1 | Cellvibrio japonicus Ueda107 |
| 83 | 2012899 | 2013090 | + | NZ_CP035494.1 | Microbacterium protaetiae |
| 84 | 3546072 | 3546263 | + | NC_006513.1 | Aromatoleum aromaticum EbN1 |
| 85 | 887606 | 887791 | - | NZ_LT615228.1 | Polynucleobacter necessarius |
| 86 | 686896 | 687081 | + | NC_009379.1 | Polynucleobacter asymbioticus QLW-P1DMWA-1 |
| 87 | 999071 | 999253 | + | NZ_AP014568.1 | Serpentinomonas raichei |
| 88 | 99142 | 99366 | - | NZ_CP022113.1 | Nitrospirillum amazonense CBAmc |
| 89 | 236027 | 236266 | - | NZ_CP023276.1 | Polynucleobacter difficilis |
| 90 | 1685113 | 1685346 | - | NZ_CP049863.1 | Leucobacter viscericola |
| 91 | 1140030 | 1140212 | + | NZ_LR134533.1 | Neisseria weaveri |
| 92 | 1939691 | 1939882 | - | NZ_CP011797.1 | Reinekea forsetii |
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| Neighborhood Conservation Analysis |
* Arrows marked in Genome Diagram shows ORFs; Multiple PFAMs can be mapped to a single ORF.
* 'Small ORF' represents the entry/query analyzed.
* Image generated using 'gggenes'(R-Package).
Neighborhood Representative Chosen(Species): NC_004851.1
| Sr.No. | Domain | Co-occurrence Frequency | No. of species in which domain occurs with smORF | Median distance b/w smORF and domain bearing ORFs | Orientation relative to smORF | PFAM Information |
|---|---|---|---|---|---|---|
| 1 | PF01850.23 | 0.89 | 79 | 0.0 | same-strand | PIN domain |
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