Result : A0R0N3
| Protein Information |
| Information Type | Description |
|---|---|
| Protein name | Antitoxin MazE |
| NCBI Accession ID | CP000480.1 |
| Organism | Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) |
| Left | 4528883 |
| Right | 4529092 |
| Strand | + |
| Nucleotide Sequence | ATGACTCCCGCGCGTGACCGAGTACGCCGACATCGCGAGCGGCTGCGGCGACAAGGTCTGCGGCCGGTGCAGATCTGGGTCCCCGACGTGAATGCACCCGAATTTCGCCGGGAGGCGCACCGGCAGTCTGAGTTGGTCGCCGCCGGCGAGCATGAGGCCGAAGATCAAGCTTTCGTCGACGCGATCTCCGTCGACTGGGACGACGCCTAA |
| Sequence | MTPARDRVRRHRERLRRQGLRPVQIWVPDVNAPEFRREAHRQSELVAAGEHEAEDQAFVDAISVDWDDA |
| Source of smORF | Swiss-Prot |
| Function | Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the effect of cognate toxin MazF. In M.smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic reactions. {ECO:0000269|Pubmed:22199354}. |
| Pubmed ID | 17295914 18955433 22199354 |
| Domain | |
| Functional Category | Antitoxin_type_2 |
| Uniprot ID | A0R0N3 |
| ORF Length (Amino Acid) | 69 |
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| Conservation Analysis |
No. of Species: 39
| Sr.No. | Left Position | Right Position | Strand | NCBI Accession id | Species Name |
|---|---|---|---|---|---|
| 1 | 4528956 | 4529165 | + | NZ_LN831039.1 | Mycolicibacterium smegmatis |
| 2 | 761679 | 761864 | - | NZ_CP016617.1 | Microvirga ossetica |
| 3 | 2006072 | 2006284 | - | NZ_AP022570.1 | Mycolicibacterium poriferae |
| 4 | 1195551 | 1195736 | + | NC_010581.1 | Beijerinckia indica subsp. indica ATCC 9039 |
| 5 | 1054627 | 1054833 | - | NZ_CP016428.1 | Bradyrhizobium icense |
| 6 | 1125007 | 1125192 | + | NC_011894.1 | Methylobacterium nodulans ORS 2060 |
| 7 | 2427897 | 2428082 | - | NZ_CP058354.1 | Bradyrhizobium japonicum |
| 8 | 4410884 | 4411069 | + | NZ_AP014946.1 | Variibacter gotjawalensis |
| 9 | 4931725 | 4931949 | - | NZ_CP015367.1 | Methylobacterium phyllosphaerae |
| 10 | 2013696 | 2013935 | + | NZ_CP030265.1 | Skermanella pratensis |
| 11 | 2539717 | 2539914 | + | NZ_CP011971.1 | Steroidobacter denitrificans |
| 12 | 22780 | 22968 | + | NZ_CP029178.1 | Acidibrevibacterium fodinaquatile |
| 13 | 3715074 | 3715259 | - | NC_009511.1 | Sphingomonas wittichii RW1 |
| 14 | 1817990 | 1818169 | - | NC_020520.1 | Ilumatobacter coccineus YM16-304 |
| 15 | 1371311 | 1371490 | + | NC_020520.1 | Ilumatobacter coccineus YM16-304 |
| 16 | 770034 | 770252 | + | NZ_HG938353.1 | Neorhizobium galegae bv. orientalis str. HAMBI 540 |
| 17 | 2205059 | 2205247 | + | NZ_CP060789.1 | Tessaracoccus defluvii |
| 18 | 373530 | 373742 | - | NZ_CP045929.1 | Saccharopolyspora coralli |
| 19 | 3334386 | 3334571 | + | NZ_AP019700.1 | Stella humosa |
| 20 | 3236703 | 3236888 | + | NZ_CP032624.1 | Gryllotalpicola protaetiae |
| 21 | 3867691 | 3867915 | - | NZ_AP022603.1 | Mycolicibacterium fallax |
| 22 | 1971481 | 1971651 | - | NZ_CP048813.1 | Rhodococcus triatomae |
| 23 | 1245544 | 1245714 | - | NZ_CP033972.1 | Gordonia insulae |
| 24 | 124928 | 125143 | - | NZ_CP007501.1 | Polynucleobacter duraquae |
| 25 | 186866 | 187102 | - | NZ_CP042304.1 | Devosia ginsengisoli |
| 26 | 152723 | 152893 | + | NC_016907.1 | Gordonia polyisoprenivorans VH2 |
| 27 | 609792 | 610004 | + | NZ_CP026538.1 | Desulfovibrio carbinolicus |
| 28 | 803742 | 803942 | + | NZ_AP022565.1 | Mycolicibacterium alvei |
| 29 | 1236358 | 1236558 | - | NZ_AP022563.1 | Mycolicibacterium duvalii |
| 30 | 2200865 | 2201083 | - | NC_016147.2 | Pseudoxanthomonas spadix BD-a59 |
| 31 | 258175 | 258387 | - | NZ_CP054615.1 | Azospirillum oryzae |
| 32 | 1970309 | 1970509 | - | NZ_AP022605.1 | Mycobacterium doricum |
| 33 | 4230002 | 4230208 | + | NZ_AP022572.1 | Mycobacterium shottsii |
| 34 | 2550748 | 2550948 | + | NZ_LR134355.1 | Mycolicibacterium chitae |
| 35 | 4352545 | 4352745 | - | NZ_AP022615.1 | Mycobacterium heidelbergense |
| 36 | 3498192 | 3498392 | - | NZ_AP022574.1 | Mycolicibacterium psychrotolerans |
| 37 | 285935 | 286135 | - | NZ_CP038213.1 | Ornithinimicrobium flavum |
| 38 | 3108111 | 3108311 | - | NC_008726.1 | Mycolicibacterium vanbaalenii PYR-1 |
| 39 | 1776443 | 1776643 | + | NZ_CP014989.1 | Serinicoccus hydrothermalis |
| 40 | 1087476 | 1087676 | + | NZ_AP022569.1 | Mycobacterium cookii |
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| Neighborhood Conservation Analysis |
* Arrows marked in Genome Diagram shows ORFs; Multiple PFAMs can be mapped to a single ORF.
* 'Small ORF' represents the entry/query analyzed.
* Image generated using 'gggenes'(R-Package).
Neighborhood Representative Chosen(Species): NZ_LN831039.1
| Sr.No. | Domain | Co-occurrence Frequency | No. of species in which domain occurs with smORF | Median distance b/w smORF and domain bearing ORFs | Orientation relative to smORF | PFAM Information |
|---|---|---|---|---|---|---|
| 1 | PF02452.19 | 0.79 | 31 | -3 | same-strand | PemK-like, MazF-like toxin of type II toxin-antitoxin system |
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