Result : Q7N2D5
| Protein Information |
| Information Type | Description |
|---|---|
| Protein name | (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase (EC 5.3.1.32) (Autoinducer 2-degrading protein LsrG) (AI-2-degrading protein LsrG) (Phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerase) (Phospho-AI-2 isomerase) |
| NCBI Accession ID | BX571869.1 |
| Organism | Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) |
| Left | 241653 |
| Right | 241952 |
| Strand | + |
| Nucleotide Sequence | ATGCACGTAACTTTGGTTGAAATTAATGTTAAGCAAGACAAATTAGACGAATTTATTGAAGTTTTTCGCCTCAATCATCTGGGATCAATTAAAGAAGCAGGCAATTTACGTTTTGATGTATTACGGGATGAAAATATCCCTACCCGCTTTTATATTTATGAAGCCTATGTTGATGAAAACGCGGCTAACACACACAAGCAAACCTCTCATTATCTGAAATGTGTTGAACAACTTGAATCTCTGATATCTGAGCCCAGGAAAAAGAGATCGTTTATTGGTGTGATGCCAGAAATAAAATAA |
| Sequence | MHVTLVEINVKQDKLDEFIEVFRLNHLGSIKEAGNLRFDVLRDENIPTRFYIYEAYVDENAANTHKQTSHYLKCVEQLESLISEPRKKRSFIGVMPEIK |
| Source of smORF | Swiss-Prot |
| Function | Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5-phosphonooxypentane-2,4-dione (P-HPD). {ECO:0000255|HAMAP-Rule:MF_02051}. |
| Pubmed ID | 14528314 |
| Domain | CDD:415830 |
| Functional Category | Others |
| Uniprot ID | Q7N2D5 |
| ORF Length (Amino Acid) | 99 |
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| Conservation Analysis |
No. of Species: 79
| Sr.No. | Left Position | Right Position | Strand | NCBI Accession id | Species Name |
|---|---|---|---|---|---|
| 1 | 3711639 | 3711938 | + | NC_005126.1 | Photorhabdus laumondii subsp. laumondii TTO1 |
| 2 | 136142 | 136441 | + | NZ_CP011104.1 | Photorhabdus thracensis |
| 3 | 1659810 | 1660109 | - | NC_012962.1 | Photorhabdus asymbiotica |
| 4 | 3908301 | 3908600 | + | NZ_FO704550.1 | Xenorhabdus doucetiae |
| 5 | 3607453 | 3607752 | + | NZ_CP016176.1 | Xenorhabdus hominickii |
| 6 | 3703077 | 3703373 | - | NZ_CP060401.1 | Xenorhabdus nematophila |
| 7 | 4049214 | 4049504 | + | NZ_CP046293.1 | Yersinia intermedia |
| 8 | 757807 | 758100 | + | NZ_CP016948.1 | Serratia surfactantfaciens |
| 9 | 3950252 | 3950551 | - | NC_013892.1 | Xenorhabdus bovienii SS-2004 |
| 10 | 1871322 | 1871612 | - | NZ_CP054043.1 | Yersinia mollaretii ATCC 43969 |
| 11 | 664145 | 664435 | - | NZ_CP043727.1 | Yersinia canariae |
| 12 | 1452492 | 1452785 | + | NZ_CP038662.1 | Serratia nematodiphila |
| 13 | 3604869 | 3605162 | - | NZ_CP071320.1 | Serratia ureilytica |
| 14 | 1478707 | 1479000 | + | NC_015567.1 | Serratia plymuthica AS9 |
| 15 | 1387669 | 1387962 | + | NZ_CP048784.1 | Serratia liquefaciens |
| 16 | 3523811 | 3524101 | - | NZ_CP009787.1 | Yersinia rohdei |
| 17 | 1461128 | 1461421 | + | NZ_LR134494.1 | Serratia quinivorans |
| 18 | 616432 | 616722 | - | NZ_CP032487.1 | Yersinia hibernica |
| 19 | 3930296 | 3930586 | + | NZ_LR134373.1 | Yersinia pseudotuberculosis |
| 20 | 2284643 | 2284933 | - | NZ_CP007230.1 | Yersinia similis |
| 21 | 1515830 | 1516123 | + | NZ_LT906479.1 | Serratia ficaria |
| 22 | 3303546 | 3303836 | - | NZ_CP009781.1 | Yersinia aldovae 670-83 |
| 23 | 324832 | 325131 | + | NZ_CP072455.1 | Xenorhabdus budapestensis |
| 24 | 2896240 | 2896533 | + | NZ_CP065640.1 | Serratia rubidaea |
| 25 | 4063660 | 4063950 | + | NZ_CP011118.1 | Yersinia enterocolitica |
| 26 | 659061 | 659354 | + | NZ_CP013990.1 | Leclercia adecarboxylata |
| 27 | 5362712 | 5363005 | + | NZ_CP011602.1 | Phytobacter ursingii |
| 28 | 4363489 | 4363779 | + | NZ_CP006569.1 | Sodalis praecaptivus |
| 29 | 5156004 | 5156294 | + | NZ_CP011254.1 | Serratia fonticola |
| 30 | 4258207 | 4258500 | - | NZ_CP063425.1 | Kosakonia pseudosacchari |
| 31 | 458703 | 458993 | + | NZ_LT556085.1 | Citrobacter amalonaticus |
| 32 | 1218613 | 1218903 | - | NZ_CP045205.1 | Citrobacter telavivensis |
| 33 | 3991166 | 3991459 | - | NZ_AP022508.1 | Enterobacter bugandensis |
| 34 | 4061222 | 4061515 | - | NZ_CP027986.1 | Enterobacter sichuanensis |
| 35 | 610502 | 610798 | + | NZ_CP054058.1 | Scandinavium goeteborgense |
| 36 | 1181392 | 1181685 | + | NZ_CP051548.1 | Phytobacter diazotrophicus |
| 37 | 2510506 | 2510799 | - | NZ_CP016337.1 | Kosakonia sacchari |
| 38 | 4075385 | 4075678 | - | NZ_CP017184.1 | Enterobacter roggenkampii |
| 39 | 4034918 | 4035211 | - | NC_015968.1 | Enterobacter soli |
| 40 | 4416491 | 4416784 | - | NZ_CP043318.1 | Enterobacter chengduensis |
| 41 | 477715 | 478005 | + | NZ_CP033744.1 | Citrobacter freundii |
| 42 | 4028806 | 4029096 | - | NZ_LR134201.1 | Cedecea lapagei |
| 43 | 4180829 | 4181122 | - | NZ_CP009756.1 | Enterobacter cloacae |
| 44 | 712063 | 712359 | + | NZ_CP060111.1 | Klebsiella michiganensis |
| 45 | 2777310 | 2777603 | - | NZ_CP023529.1 | Lelliottia amnigena |
| 46 | 4289122 | 4289412 | + | NC_003197.2 | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
| 47 | 4282789 | 4283082 | + | NZ_CP045769.1 | Enterobacter cancerogenus |
| 48 | 3727012 | 3727305 | + | NZ_CP045300.1 | Kosakonia arachidis |
| 49 | 3230444 | 3230737 | + | NZ_CP025034.2 | Enterobacter sp. SGAir0187 |
| 50 | 1807483 | 1807776 | - | NZ_AP019007.1 | Enterobacter oligotrophicus |
| 51 | 582049 | 582339 | - | NZ_CP057657.1 | Escherichia fergusonii |
| 52 | 4331008 | 4331301 | + | NZ_CP017279.1 | Enterobacter ludwigii |
| 53 | 3968739 | 3969035 | - | NZ_CP012871.1 | [Enterobacter] lignolyticus |
| 54 | 583893 | 584183 | + | NZ_AP023184.1 | Buttiauxella agrestis |
| 55 | 616950 | 617246 | + | NZ_CP065838.1 | Klebsiella quasipneumoniae |
| 56 | 612592 | 612888 | + | NZ_LR134475.1 | Klebsiella aerogenes |
| 57 | 4659265 | 4659561 | - | NC_016845.1 | Klebsiella pneumoniae subsp. pneumoniae HS11286 |
| 58 | 4690436 | 4690729 | - | NZ_CP015113.1 | Kosakonia radicincitans |
| 59 | 623538 | 623834 | + | NZ_CP054254.1 | Klebsiella variicola |
| 60 | 636041 | 636334 | + | NZ_CP014007.2 | Kosakonia oryzae |
| 61 | 2755463 | 2755753 | + | NZ_CP016043.1 | Edwardsiella hoshinae |
| 62 | 2120883 | 2121173 | - | NZ_CP061527.1 | Shigella dysenteriae |
| 63 | 1606999 | 1607289 | + | NC_000913.3 | Escherichia coli str. K-12 substr. MG1655 |
| 64 | 2131058 | 2131348 | + | NC_002695.2 | Escherichia coli O157:H7 str. Sakai |
| 65 | 943129 | 943419 | + | NZ_CP067057.1 | Rahnella aceris |
| 66 | 765281 | 765577 | + | NZ_CP036175.1 | Klebsiella huaxiensis |
| 67 | 2285459 | 2285752 | + | NZ_CP042941.1 | Atlantibacter hermannii |
| 68 | 1609176 | 1609466 | - | NC_004337.2 | Shigella flexneri 2a str. 301 |
| 69 | 622873 | 623166 | + | NZ_CP050508.1 | Raoultella terrigena |
| 70 | 1069497 | 1069790 | - | NZ_CP026047.1 | Raoultella planticola |
| 71 | 652114 | 652407 | + | NZ_CP046672.1 | Raoultella ornithinolytica |
| 72 | 603661 | 603954 | + | NZ_CP041247.1 | Raoultella electrica |
| 73 | 4321410 | 4321700 | - | NZ_CP023525.1 | Cedecea neteri |
| 74 | 798538 | 798852 | - | NZ_CP028926.1 | Pasteurella multocida |
| 75 | 1724975 | 1725283 | + | NZ_CP016180.1 | Pasteurella skyensis |
| 76 | 82012 | 82314 | + | NZ_CP018804.1 | Histophilus somni |
| 77 | 1669355 | 1669663 | - | NZ_LR134327.1 | Aggregatibacter aphrophilus ATCC 33389 |
| 78 | 368063 | 368362 | - | NZ_LR134167.1 | Avibacterium volantium |
| 79 | 3243874 | 3244173 | - | NC_019902.2 | Thioalkalivibrio nitratireducens DSM 14787 |
| 80 | 1617267 | 1617581 | - | NZ_LS974202.1 | Mesotoga infera |
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| Neighborhood Conservation Analysis |
* Arrows marked in Genome Diagram shows ORFs; Multiple PFAMs can be mapped to a single ORF.
* 'Small ORF' represents the entry/query analyzed.
* Image generated using 'gggenes'(R-Package).
Neighborhood Representative Chosen(Species): NC_005126.1
| Sr.No. | Domain | Co-occurrence Frequency | No. of species in which domain occurs with smORF | Median distance b/w smORF and domain bearing ORFs | Orientation relative to smORF | PFAM Information |
|---|---|---|---|---|---|---|
| 1 | PF00005.29 | 0.73 | 58 | 3954.5 | same-strand | ABC transporter |
| 2 | PF02653.18 | 0.71 | 56 | 2877 | same-strand | Branched-chain amino acid transport system / permease component |
| 3 | PF13407.8 | 0.71 | 56 | 911.0 | same-strand | Periplasmic binding protein domain |
| 4 | PF01791.11 | 0.87 | 69 | -0.5 | same-strand | DeoC/LacD family aldolase |
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