ProsmORF-pred
Result : Q79FR3
Protein Information
Information Type Description
Protein name PE family protein PE13
NCBI Accession ID AL123456.3
Organism Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Left 1339003
Right 1339302
Strand +
Nucleotide Sequence GTGTCTTTCGTGATGGCATACCCAGAGATGTTGGCGGCGGCGGCTGACACCCTGCAGAGCATCGGTGCTACCACTGTGGCTAGCAATGCCGCTGCGGCGGCCCCGACGACTGGGGTGGTGCCCCCCGCTGCCGATGAGGTGTCGGCGCTGACTGCGGCGCACTTCGCCGCACATGCGGCGATGTATCAGTCCGTGAGCGCTCGGGCTGCTGCGATTCATGACCAGTTCGTGGCCACCCTTGCCAGCAGCGCCAGCTCGTATGCGGCCACTGAAGTCGCCAATGCGGCGGCGGCCAGCTAA
Sequence MSFVMAYPEMLAAAADTLQSIGATTVASNAAAAAPTTGVVPPAADEVSALTAAHFAAHAAMYQSVSARAAAIHDQFVATLASSASSYAATEVANAAAAS
Source of smORF Swiss-Prot
Function May play a pivotal role in the interaction between M.tuberculosis and host. Can enhance the survival within macrophages under stress conditions such as H(2)O(2), SDS and low pH. Increases the production of IL-6 and IL-1beta from macrophages, and decreases the secretion of suppressor of cytokine signaling 3 (SOCS-3). These changes probably involve the p38-ERK-NF-kappa-B signaling pathway. Also precipitates the macrophage death. {ECO:0000269|Pubmed:27147522}.
Pubmed ID 9634230 19651861 21969609 27147522
Domain CDD:395748
Functional Category Others
Uniprot ID Q79FR3
ORF Length (Amino Acid) 99
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Conservation Analysis
Conservation Analysis
No. of Species: 35
Sr.No. Left Position Right Position Strand NCBI Accession id Species Name
1 1339003 1339302 + NC_000962.3 Mycobacterium tuberculosis H37Rv
2 3894093 3894389 + NC_000962.3 Mycobacterium tuberculosis H37Rv
3 2026477 2026776 + NC_000962.3 Mycobacterium tuberculosis H37Rv
4 2029904 2030203 + NC_000962.3 Mycobacterium tuberculosis H37Rv
5 4061899 4062198 - NC_000962.3 Mycobacterium tuberculosis H37Rv
6 2048072 2048371 + NC_000962.3 Mycobacterium tuberculosis H37Rv
7 1359059 1359358 + NC_015848.1 Mycobacterium canettii CIPT 140010059
8 3951998 3952294 + NC_015848.1 Mycobacterium canettii CIPT 140010059
9 2069426 2069725 + NC_015848.1 Mycobacterium canettii CIPT 140010059
10 2072863 2073162 + NC_015848.1 Mycobacterium canettii CIPT 140010059
11 4117299 4117598 - NC_015848.1 Mycobacterium canettii CIPT 140010059
12 2088202 2088501 + NC_015848.1 Mycobacterium canettii CIPT 140010059
13 1611514 1611813 - NC_022663.1 Mycobacterium kansasii ATCC 12478
14 48417 48716 + NC_022663.1 Mycobacterium kansasii ATCC 12478
15 2301665 2301964 - NC_022663.1 Mycobacterium kansasii ATCC 12478
16 2763655 2763954 + NC_022663.1 Mycobacterium kansasii ATCC 12478
17 2087975 2088274 + NC_022663.1 Mycobacterium kansasii ATCC 12478
18 2762240 2762539 - NC_022663.1 Mycobacterium kansasii ATCC 12478
19 46485 46784 + NC_022663.1 Mycobacterium kansasii ATCC 12478
20 4411874 4412173 - NC_022663.1 Mycobacterium kansasii ATCC 12478
21 4258668 4258967 - NZ_LR130759.1 Mycobacterium basiliense
22 2786983 2787282 + NZ_LR130759.1 Mycobacterium basiliense
23 4612205 4612504 + NZ_LR130759.1 Mycobacterium basiliense
24 2792785 2793084 + NZ_LR130759.1 Mycobacterium basiliense
25 5142762 5143061 - NZ_LR130759.1 Mycobacterium basiliense
26 1904381 1904641 - NZ_LR130759.1 Mycobacterium basiliense
27 5145699 5145998 - NZ_LR130759.1 Mycobacterium basiliense
28 2086309 2086596 - NZ_LR130759.1 Mycobacterium basiliense
29 642116 642415 - NZ_CP058277.1 Mycobacterium marinum
30 4632685 4632984 + NZ_CP058277.1 Mycobacterium marinum
31 4635181 4635480 + NZ_CP058277.1 Mycobacterium marinum
32 1011454 1011753 - NZ_CP058277.1 Mycobacterium marinum
33 452348 452647 + NZ_CP058277.1 Mycobacterium marinum
34 1014455 1014754 - NZ_CP058277.1 Mycobacterium marinum
35 54413 54712 - NZ_CP058277.1 Mycobacterium marinum
36 3475604 3475897 - NZ_AP022583.1 Mycobacterium noviomagense
37 4225809 4226105 + NZ_AP022583.1 Mycobacterium noviomagense
38 4206857 4207156 + NZ_AP022583.1 Mycobacterium noviomagense
39 4209881 4210180 + NZ_AP022583.1 Mycobacterium noviomagense
40 4243892 4244191 + NZ_AP022583.1 Mycobacterium noviomagense
41 2982182 2982481 + NZ_AP018410.1 Mycobacterium pseudoshottsii JCM 15466
42 5377215 5377514 - NZ_AP018410.1 Mycobacterium pseudoshottsii JCM 15466
43 2986054 2986353 + NZ_AP018410.1 Mycobacterium pseudoshottsii JCM 15466
44 385289 385588 + NZ_AP018410.1 Mycobacterium pseudoshottsii JCM 15466
45 5190408 5190707 + NZ_AP018410.1 Mycobacterium pseudoshottsii JCM 15466
46 382216 382515 + NZ_AP018410.1 Mycobacterium pseudoshottsii JCM 15466
47 1754515 1754811 + NZ_AP018410.1 Mycobacterium pseudoshottsii JCM 15466
48 4132265 4132564 - NZ_AP022606.1 Mycobacterium branderi
49 4147153 4147452 - NZ_AP022606.1 Mycobacterium branderi
50 4120624 4120923 - NZ_AP022606.1 Mycobacterium branderi
51 2542528 2542827 - NZ_AP022606.1 Mycobacterium branderi
52 4122936 4123235 - NZ_AP022606.1 Mycobacterium branderi
53 2607839 2608138 - NZ_AP022606.1 Mycobacterium branderi
54 2610296 2610595 - NZ_AP022606.1 Mycobacterium branderi
55 4141980 4142279 - NZ_AP022606.1 Mycobacterium branderi
56 4137896 4138195 - NZ_AP022606.1 Mycobacterium branderi
57 2605388 2605660 + NZ_AP022606.1 Mycobacterium branderi
58 4917333 4917590 - NZ_AP022606.1 Mycobacterium branderi
59 4114436 4114735 - NZ_AP022606.1 Mycobacterium branderi
60 775649 775945 - NZ_AP022606.1 Mycobacterium branderi
61 105215 105514 - NZ_AP022575.1 Mycobacterium shinjukuense
62 1421610 1421909 + NZ_AP022575.1 Mycobacterium shinjukuense
63 1548652 1548951 - NZ_AP022575.1 Mycobacterium shinjukuense
64 1550491 1550790 - NZ_AP022575.1 Mycobacterium shinjukuense
65 3344193 3344504 + NZ_AP022575.1 Mycobacterium shinjukuense
66 4162570 4162869 + NZ_AP022575.1 Mycobacterium shinjukuense
67 3698054 3698359 - NZ_AP022575.1 Mycobacterium shinjukuense
68 1535916 1536206 - NZ_AP022575.1 Mycobacterium shinjukuense
69 2083354 2083653 - NZ_AP022581.1 Mycobacterium lacus
70 860876 861148 + NZ_AP022581.1 Mycobacterium lacus
71 1856540 1856839 + NZ_AP022581.1 Mycobacterium lacus
72 416873 417172 - NZ_AP022581.1 Mycobacterium lacus
73 1854622 1854921 + NZ_AP022581.1 Mycobacterium lacus
74 4222926 4223225 + NZ_AP022581.1 Mycobacterium lacus
75 4976360 4976659 + NZ_AP022581.1 Mycobacterium lacus
76 4941405 4941749 - NZ_AP022581.1 Mycobacterium lacus
77 2830361 2830660 + NZ_AP022613.1 Mycobacterium conspicuum
78 2825240 2825539 + NZ_AP022613.1 Mycobacterium conspicuum
79 2828525 2828824 + NZ_AP022613.1 Mycobacterium conspicuum
80 3137451 3137750 + NZ_AP022613.1 Mycobacterium conspicuum
81 355666 355983 + NZ_AP022613.1 Mycobacterium conspicuum
82 2844937 2845236 + NZ_AP022613.1 Mycobacterium conspicuum
83 906014 906313 + NZ_AP022569.1 Mycobacterium cookii
84 901985 902284 + NZ_AP022569.1 Mycobacterium cookii
85 75406 75705 - NZ_AP022569.1 Mycobacterium cookii
86 40870 41169 - NZ_AP022569.1 Mycobacterium cookii
87 917296 917595 + NZ_AP022569.1 Mycobacterium cookii
88 4540965 4541264 + NZ_AP022569.1 Mycobacterium cookii
89 2309516 2309815 - NZ_AP022569.1 Mycobacterium cookii
90 171776 172075 + NZ_AP022569.1 Mycobacterium cookii
91 898283 898582 + NZ_AP022569.1 Mycobacterium cookii
92 368580 368879 + NZ_AP022569.1 Mycobacterium cookii
93 1989226 1989501 + NZ_AP022569.1 Mycobacterium cookii
94 1237638 1237937 + NZ_AP022590.1 Mycobacterium mantenii
95 1232367 1232666 + NZ_AP022590.1 Mycobacterium mantenii
96 5095438 5095737 + NZ_AP022590.1 Mycobacterium mantenii
97 1511201 1511500 + NZ_AP022582.1 Mycobacterium seoulense
98 1506006 1506305 + NZ_AP022582.1 Mycobacterium seoulense
99 3775031 3775330 - NZ_AP022582.1 Mycobacterium seoulense
100 5056271 5056573 + NZ_AP022582.1 Mycobacterium seoulense
101 908621 908920 + NZ_AP022562.1 Mycobacterium novum
102 2093273 2093569 - NZ_AP022562.1 Mycobacterium novum
103 3882663 3882962 + NZ_AP022562.1 Mycobacterium novum
104 4393676 4393975 - NZ_AP022562.1 Mycobacterium novum
105 4384804 4385103 - NZ_AP022562.1 Mycobacterium novum
106 3726091 3726390 - NZ_AP022562.1 Mycobacterium novum
107 741148 741447 - NZ_AP022562.1 Mycobacterium novum
108 912292 912591 + NZ_AP022562.1 Mycobacterium novum
109 3314789 3315088 - NZ_AP022562.1 Mycobacterium novum
110 2458538 2458837 - NZ_AP022562.1 Mycobacterium novum
111 1077070 1077369 - NC_015576.1 Mycolicibacter sinensis
112 2565229 2565528 - NC_015576.1 Mycolicibacter sinensis
113 4520629 4520925 + NC_015576.1 Mycolicibacter sinensis
114 2073496 2073795 + NC_015576.1 Mycolicibacter sinensis
115 2720199 2720498 + NC_015576.1 Mycolicibacter sinensis
116 1241515 1241814 + NC_015576.1 Mycolicibacter sinensis
117 2064619 2064918 + NC_015576.1 Mycolicibacter sinensis
118 1073399 1073698 - NC_015576.1 Mycolicibacter sinensis
119 3162454 3162753 + NC_015576.1 Mycolicibacter sinensis
120 4169376 4169675 + NC_015576.1 Mycolicibacter sinensis
121 1040468 1040767 - NZ_LT906469.1 Mycolicibacter terrae
122 2459541 2459840 + NZ_LT906469.1 Mycolicibacter terrae
123 1991533 1991832 + NZ_LT906469.1 Mycolicibacter terrae
124 2000507 2000806 + NZ_LT906469.1 Mycolicibacter terrae
125 2483741 2484040 - NZ_LT906469.1 Mycolicibacter terrae
126 1169145 1169444 + NZ_LT906469.1 Mycolicibacter terrae
127 4010786 4011085 + NZ_LT906469.1 Mycolicibacter terrae
128 3082408 3082707 + NZ_LT906469.1 Mycolicibacter terrae
129 3906570 3906869 + NZ_AP022572.1 Mycobacterium shottsii
130 3909066 3909365 + NZ_AP022572.1 Mycobacterium shottsii
131 578520 578819 - NZ_AP022572.1 Mycobacterium shottsii
132 2150391 2150690 - NZ_AP022572.1 Mycobacterium shottsii
133 581520 581819 - NZ_AP022572.1 Mycobacterium shottsii
134 1445884 1446180 + NZ_AP022572.1 Mycobacterium shottsii
135 2535588 2535887 - NZ_CP009360.4 Mycobacterium avium subsp. hominissuis
136 2722913 2723182 + NZ_CP009360.4 Mycobacterium avium subsp. hominissuis
137 2525081 2525380 - NZ_CP009360.4 Mycobacterium avium subsp. hominissuis
138 462667 462966 + NZ_CP009360.4 Mycobacterium avium subsp. hominissuis
139 2654651 2654950 - NZ_CP023147.1 Mycobacterium marseillense
140 1375245 1375544 - NZ_CP023147.1 Mycobacterium marseillense
141 788337 788636 + NZ_AP022619.1 Mycobacterium paraseoulense
142 783119 783418 + NZ_AP022619.1 Mycobacterium paraseoulense
143 3612664 3612963 - NZ_AP022619.1 Mycobacterium paraseoulense
144 4854893 4855195 + NZ_AP022619.1 Mycobacterium paraseoulense
145 3397148 3397447 + NZ_CP025546.1 Mycobacterium paragordonae
146 5685108 5685407 + NZ_CP025546.1 Mycobacterium paragordonae
147 3389594 3389893 + NZ_CP025546.1 Mycobacterium paragordonae
148 5543198 5543497 + NZ_CP025546.1 Mycobacterium paragordonae
149 6299475 6299774 - NZ_CP025546.1 Mycobacterium paragordonae
150 3660904 3661200 - NZ_CP025546.1 Mycobacterium paragordonae
151 6257064 6257363 - NZ_CP025546.1 Mycobacterium paragordonae
152 46830 47129 - NZ_AP022589.1 Mycolicibacter minnesotensis
153 3829163 3829462 + NZ_AP022589.1 Mycolicibacter minnesotensis
154 3820259 3820558 + NZ_AP022589.1 Mycolicibacter minnesotensis
155 1762737 1763036 + NZ_AP022589.1 Mycolicibacter minnesotensis
156 2816945 2817244 - NZ_AP022589.1 Mycolicibacter minnesotensis
157 644901 645200 + NZ_AP022589.1 Mycolicibacter minnesotensis
158 653534 653839 + NZ_AP022589.1 Mycolicibacter minnesotensis
159 2869770 2870069 - NC_016946.1 Mycobacterium intracellulare ATCC 13950
160 1644521 1644820 - NC_016946.1 Mycobacterium intracellulare ATCC 13950
161 2711978 2712277 + NC_016946.1 Mycobacterium intracellulare ATCC 13950
162 451467 451766 + NC_016946.1 Mycobacterium intracellulare ATCC 13950
163 2749557 2749856 - NC_016948.1 Mycobacterium paraintracellulare
164 1399337 1399636 - NC_016948.1 Mycobacterium paraintracellulare
165 2591761 2592060 + NC_016948.1 Mycobacterium paraintracellulare
166 460209 460508 + NC_016948.1 Mycobacterium paraintracellulare
167 677450 677749 - NZ_AP022576.1 Mycobacterium florentinum
168 684362 684661 - NZ_AP022576.1 Mycobacterium florentinum
169 4191154 4191453 + NZ_AP022576.1 Mycobacterium florentinum
170 1699142 1699441 - NZ_AP022576.1 Mycobacterium florentinum
171 1607912 1608220 - NZ_AP022576.1 Mycobacterium florentinum
172 500120 500419 + NZ_AP022609.1 Mycolicibacter hiberniae
173 1473223 1473522 + NZ_AP022609.1 Mycolicibacter hiberniae
174 1482081 1482380 + NZ_AP022609.1 Mycolicibacter hiberniae
175 1929566 1929865 - NZ_AP022609.1 Mycolicibacter hiberniae
176 2094274 2094573 + NZ_AP022609.1 Mycolicibacter hiberniae
177 572469 572768 - NZ_AP022609.1 Mycolicibacter hiberniae
178 2499264 2499563 + NZ_AP022609.1 Mycolicibacter hiberniae
179 1554215 1554514 - NZ_AP022614.1 Mycobacterium parmense
180 5832271 5832570 + NZ_AP022614.1 Mycobacterium parmense
181 1559597 1559896 - NZ_AP022614.1 Mycobacterium parmense
182 4576112 4576411 - NZ_AP022615.1 Mycobacterium heidelbergense
183 4589964 4590263 - NZ_AP022615.1 Mycobacterium heidelbergense
184 4577981 4578280 - NZ_AP022615.1 Mycobacterium heidelbergense
185 5002974 5003273 - NZ_AP022615.1 Mycobacterium heidelbergense
186 720609 720908 + NZ_AP022573.1 Mycobacterium saskatchewanense
187 3243389 3243688 - NZ_AP022573.1 Mycobacterium saskatchewanense
188 705100 705399 + NZ_AP022573.1 Mycobacterium saskatchewanense
189 1463623 1463922 + NZ_AP022573.1 Mycobacterium saskatchewanense
190 719958 720257 + NZ_AP022573.1 Mycobacterium saskatchewanense
191 3158248 3158547 - NZ_AP022573.1 Mycobacterium saskatchewanense
192 3477127 3477417 - NZ_AP022573.1 Mycobacterium saskatchewanense
193 782815 783114 - NZ_AP022587.1 Mycobacterium stomatepiae
194 510314 510613 + NZ_AP022587.1 Mycobacterium stomatepiae
195 784822 785121 - NZ_AP022587.1 Mycobacterium stomatepiae
196 4464551 4464850 + NZ_AP022587.1 Mycobacterium stomatepiae
197 1780858 1781157 - NZ_AP022587.1 Mycobacterium stomatepiae
198 1689694 1690002 - NZ_AP022587.1 Mycobacterium stomatepiae
199 512415 512714 - NZ_AP022607.1 Mycobacterium branderi
200 500205 500504 + NZ_AP022607.1 Mycobacterium branderi
201 493908 494207 - NZ_AP022607.1 Mycobacterium branderi
202 5569560 5569859 - NZ_AP022568.1 Mycobacterium simiae
203 5574528 5574827 - NZ_AP022568.1 Mycobacterium simiae
204 3055311 3055610 + NZ_AP022568.1 Mycobacterium simiae
205 749868 750167 - NZ_AP022568.1 Mycobacterium simiae
206 658314 658613 - NZ_AP022568.1 Mycobacterium simiae
207 5314623 5314919 - NZ_AP022568.1 Mycobacterium simiae
208 2729881 2730180 + NZ_AP018164.1 Mycobacterium shigaense
209 466017 466328 - NZ_CP011883.2 Mycobacterium haemophilum DSM 44634
210 1065727 1066029 - NZ_CP011883.2 Mycobacterium haemophilum DSM 44634
211 2206253 2206552 + NZ_CP011883.2 Mycobacterium haemophilum DSM 44634
212 2956597 2956893 + NZ_CP011883.2 Mycobacterium haemophilum DSM 44634
213 932064 932363 - NZ_CP011883.2 Mycobacterium haemophilum DSM 44634
214 2215572 2215871 + NZ_CP011883.2 Mycobacterium haemophilum DSM 44634
215 286332 286640 - NZ_CP011883.2 Mycobacterium haemophilum DSM 44634
216 2648756 2649055 - NZ_AP024310.1 Mycobacterium heckeshornense
217 2663350 2663649 - NZ_AP024310.1 Mycobacterium heckeshornense
218 2666329 2666628 - NZ_AP024310.1 Mycobacterium heckeshornense
219 2230462 2230773 + NZ_AP024310.1 Mycobacterium heckeshornense
220 3388951 3389250 + NZ_AP024310.1 Mycobacterium heckeshornense
221 440877 441176 + NZ_AP024310.1 Mycobacterium heckeshornense
222 3780336 3780638 + NZ_AP024310.1 Mycobacterium heckeshornense
223 1310387 1310635 + NZ_AP024310.1 Mycobacterium heckeshornense
224 250774 251073 - NZ_CP025547.1 Mycobacterium paragordonae
225 68005 68253 - NC_022654.1 Mycobacterium kansasii ATCC 12478
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Neighborhood Conservation Analysis
* Arrows marked in Genome Diagram shows ORFs; Multiple PFAMs can be mapped to a single ORF.
* 'Small ORF' represents the entry/query analyzed.
* Image generated using 'gggenes'(R-Package).
Neighborhood Conservation Analysis
Neighborhood Representative Chosen(Species): NZ_CP058277.1
Sr.No. Domain Co-occurrence Frequency No. of species in which domain occurs with smORF Median distance b/w smORF and domain bearing ORFs Orientation relative to smORF PFAM Information
1 PF00823.21 1.0 35 404.5 same-strand PPE family
2 PF12484.10 1.0 35 397 same-strand PPE-SVP subfamily C-terminal region
3 PF06013.14 1.0 35 1229 same-strand Proteins of 100 residues with WXG
4 PF05108.15 0.69 24 7503 same-strand Type VII secretion system ESX-1, transport TM domain B
5 PF01580.20 0.8 28 3476.5 same-strand FtsK/SpoIIIE family
6 PF13459.8 0.69 24 1973.5 same-strand 4Fe-4S single cluster domain
7 PF13370.8 0.69 24 1973.5 same-strand 4Fe-4S single cluster domain of Ferredoxin I
8 PF00934.22 0.83 29 2725.0 same-strand PE family
9 PF14011.8 1.0 35 1049.5 same-strand EspG family
10 PF08817.12 1.0 35 2210.5 same-strand WXG100 protein secretion system (Wss), protein YukD
11 PF19053.2 0.89 31 2202 same-strand EccD-like transmembrane domain
12 PF04402.16 0.6 21 927 opposite-strand Protein of unknown function (DUF541)
13 PF05305.16 0.6 21 1406 same-strand Protein of unknown function (DUF732)
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