Result : Q5SH22
| Protein Information |
| Information Type | Description |
|---|---|
| Protein name | Alpha-aminoadipate carrier protein LysW (AAA carrier protein LysW) |
| NCBI Accession ID | AP008226.1 |
| Organism | Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) |
| Left | 1792681 |
| Right | 1792845 |
| Strand | - |
| Nucleotide Sequence | ATGGTAGGAACCTGCCCTGAGTGCGGTGCGGAACTGCGGCTGGAGAACCCGGAGCTTGGCGAGCTTGTGGTCTGCGAGGACTGCGGCGCGGAGCTTGAGGTGGTGGGGCTTGACCCCTTGAGGCTCGAGCCCGCCCCGGAGGAGGCGGAAGACTGGGGCGAGTGA |
| Sequence | MVGTCPECGAELRLENPELGELVVCEDCGAELEVVGLDPLRLEPAPEEAEDWGE |
| Source of smORF | Swiss-Prot |
| Function | Carrier protein that bears the covalently bound substrates for lysine biosynthesis; the bound alpha-aminoadipate (AAA) is sequentially converted to L-lysine. {ECO:0000269|Pubmed:19620981}. |
| Pubmed ID | 19620981 |
| Domain | CDD:400527,CDD:275955 |
| Functional Category | Metal-binding |
| Uniprot ID | Q5SH22 |
| ORF Length (Amino Acid) | 54 |
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| Conservation Analysis |
No. of Species: 96
| Sr.No. | Left Position | Right Position | Strand | NCBI Accession id | Species Name |
|---|---|---|---|---|---|
| 1 | 1792681 | 1792845 | - | NC_006461.1 | Thermus thermophilus HB8 |
| 2 | 811716 | 811880 | - | NZ_CP016312.1 | Thermus brockianus |
| 3 | 1992220 | 1992384 | + | NZ_CP038452.1 | Thermus caldilimi |
| 4 | 1844147 | 1844311 | - | NC_019386.1 | Thermus oshimai JL-2 |
| 5 | 72922 | 73086 | + | NZ_CP010822.1 | Thermus aquaticus Y51MC23 |
| 6 | 213980 | 214144 | + | NZ_CP014141.1 | Thermus parvatiensis |
| 7 | 1797369 | 1797527 | + | NC_014761.1 | Oceanithermus profundus DSM 14977 |
| 8 | 646962 | 647132 | - | NC_015387.1 | Marinithermus hydrothermalis DSM 14884 |
| 9 | 1712750 | 1712923 | + | NZ_CP029494.1 | Deinococcus irradiatisoli |
| 10 | 446837 | 447010 | - | NC_014212.1 | Meiothermus silvanus DSM 9946 |
| 11 | 1668976 | 1669149 | + | NC_017790.1 | Deinococcus gobiensis I-0 |
| 12 | 2763449 | 2763613 | - | NC_019793.1 | Deinococcus peraridilitoris DSM 19664 |
| 13 | 1388110 | 1388283 | + | NZ_CP031500.1 | Deinococcus radiodurans |
| 14 | 1460113 | 1460286 | - | NC_014958.1 | Deinococcus maricopensis DSM 21211 |
| 15 | 411418 | 411591 | - | NZ_CP011389.1 | Deinococcus soli (ex Cha et al. 2016) |
| 16 | 1589353 | 1589526 | + | NZ_CP013910.1 | Deinococcus actinosclerus |
| 17 | 1441948 | 1442121 | - | NZ_CP021081.1 | Deinococcus ficus |
| 18 | 339527 | 339703 | + | NC_013525.1 | Thermobaculum terrenum ATCC BAA-798 |
| 19 | 1629566 | 1629739 | + | NZ_CP010028.1 | Deinococcus radiopugnans |
| 20 | 1907438 | 1907611 | - | NZ_CP011387.1 | Deinococcus puniceus |
| 21 | 176303 | 176467 | + | NC_021921.1 | Halorhabdus tiamatea SARL4B |
| 22 | 1225621 | 1225794 | - | NC_008025.1 | Deinococcus geothermalis DSM 11300 |
| 23 | 1641749 | 1641922 | - | NC_012526.1 | Deinococcus deserti VCD115 |
| 24 | 170465 | 170629 | + | NC_013158.1 | Halorhabdus utahensis DSM 12940 |
| 25 | 1832447 | 1832593 | - | NZ_LN999010.1 | Thermococcus chitonophagus |
| 26 | 1502251 | 1502406 | - | NC_011959.1 | Thermomicrobium roseum DSM 5159 |
| 27 | 239479 | 239640 | + | NC_013523.1 | Sphaerobacter thermophilus DSM 20745 |
| 28 | 2059473 | 2059637 | + | NZ_CP058335.1 | Natronomonas salina |
| 29 | 1555268 | 1555432 | - | NZ_CP058334.1 | Natronomonas halophila |
| 30 | 1403392 | 1403559 | - | NC_014960.1 | Anaerolinea thermophila UNI-1 |
| 31 | 2398999 | 2399163 | + | NZ_LN831302.1 | Halobacterium hubeiense |
| 32 | 2544790 | 2544954 | + | NC_007426.1 | Natronomonas pharaonis DSM 2160 |
| 33 | 2941776 | 2941910 | - | NZ_CP019154.1 | Haloarcula taiwanensis |
| 34 | 2970758 | 2970892 | - | NC_015948.1 | Haloarcula hispanica ATCC 33960 |
| 35 | 2668842 | 2668976 | + | NZ_CP073366.1 | Haloarcula sinaiiensis ATCC 33800 |
| 36 | 2386245 | 2386379 | - | NC_006396.1 | Haloarcula marismortui ATCC 43049 |
| 37 | 3231713 | 3231847 | + | NZ_CP034345.1 | Haloplanus rallus |
| 38 | 3754911 | 3755060 | + | NZ_CP018099.1 | Caldithrix abyssi DSM 13497 |
| 39 | 2443422 | 2443556 | - | NZ_CP034145.1 | Haloplanus aerogenes |
| 40 | 209236 | 209403 | - | NC_018178.1 | Melioribacter roseus P3M-2 |
| 41 | 950708 | 950872 | - | NC_018024.1 | Acetomicrobium mobile DSM 13181 |
| 42 | 2810591 | 2810755 | - | NZ_CP031150.1 | Haloplanus rubicundus |
| 43 | 742882 | 743046 | + | NC_013202.1 | Halomicrobium mukohataei DSM 12286 |
| 44 | 1739261 | 1739413 | - | NZ_AP018437.1 | Pelolinea submarina |
| 45 | 1547016 | 1547183 | + | NZ_CP023154.1 | Pyrococcus furiosus DSM 3638 |
| 46 | 233432 | 233590 | - | NC_006624.1 | Thermococcus kodakarensis KOD1 |
| 47 | 4375850 | 4376017 | - | NC_011831.1 | Chloroflexus aggregans DSM 9485 |
| 48 | 4376100 | 4376267 | - | NC_011831.1 | Chloroflexus aggregans DSM 9485 |
| 49 | 2877229 | 2877396 | + | NZ_CP016757.1 | Cloacibacillus porcorum |
| 50 | 2065608 | 2065772 | + | NZ_CP016804.1 | Halodesulfurarchaeum formicicum |
| 51 | 2097179 | 2097313 | + | NZ_CP011564.1 | Halanaeroarchaeum sulfurireducens |
| 52 | 2468577 | 2468756 | + | NC_017030.1 | Corallococcus coralloides DSM 2259 |
| 53 | 3481039 | 3481173 | + | NZ_CP024047.1 | Natrarchaeobaculum sulfurireducens |
| 54 | 1009187 | 1009321 | - | NZ_CP045488.1 | Natronorubrum aibiense |
| 55 | 3305555 | 3305719 | - | NZ_CP040637.1 | Natrinema pallidum |
| 56 | 3609075 | 3609209 | - | NC_019962.1 | Natrinema pellirubrum DSM 15624 |
| 57 | 1545787 | 1545921 | + | NZ_CP031305.1 | Natronorubrum bangense |
| 58 | 4531127 | 4531294 | - | NC_009767.1 | Roseiflexus castenholzii DSM 13941 |
| 59 | 1669933 | 1670067 | - | NZ_CP019893.1 | Natrarchaeobaculum aegyptiacum |
| 60 | 684885 | 685019 | + | NC_015666.1 | Halopiger xanaduensis SH-6 |
| 61 | 143680 | 143814 | + | NC_019974.1 | Natronococcus occultus SP4 |
| 62 | 2590756 | 2590890 | - | NZ_CP019327.1 | Haloterrigena daqingensis |
| 63 | 348037 | 348171 | - | NC_013743.1 | Haloterrigena turkmenica DSM 5511 |
| 64 | 1544014 | 1544148 | + | NZ_CP069188.1 | Haloterrigena salifodinae |
| 65 | 2259141 | 2259305 | - | NZ_CP071463.1 | Haloterrigena longa |
| 66 | 1675905 | 1676069 | + | NZ_CP065856.1 | Halosimplex litoreum |
| 67 | 875043 | 875207 | + | NZ_CP058910.1 | Halosimplex rubrum |
| 68 | 856679 | 856843 | + | NZ_CP058909.1 | Halosimplex pelagicum |
| 69 | 1795710 | 1795874 | - | NC_013922.1 | Natrialba magadii ATCC 43099 |
| 70 | 902747 | 902881 | - | NZ_CP019285.1 | Halobiforma lacisalsi AJ5 |
| 71 | 1537383 | 1537550 | + | NC_016148.1 | Thermovirga lienii DSM 17291 |
| 72 | 2538378 | 2538512 | - | NZ_CP058529.1 | Halobaculum halophilum |
| 73 | 145997 | 146161 | + | NZ_CP007055.1 | Halostagnicola larsenii XH-48 |
| 74 | 6347109 | 6347273 | - | NC_019673.1 | Saccharothrix espanaensis DSM 44229 |
| 75 | 1597746 | 1597910 | + | NC_019792.1 | Natronobacterium gregoryi SP2 |
| 76 | 442199 | 442333 | - | NZ_CP058579.1 | Halobaculum salinum |
| 77 | 49065 | 49199 | - | NZ_CP025066.1 | Halalkaliarchaeum desulfuricum |
| 78 | 600750 | 600911 | + | NC_017079.1 | Caldilinea aerophila DSM 14535 = NBRC 104270 |
| 79 | 1512127 | 1512291 | - | NC_000961.1 | Pyrococcus horikoshii OT3 |
| 80 | 23989 | 24153 | - | NZ_CP015867.1 | Streptomyces parvulus |
| 81 | 1535274 | 1535408 | + | NZ_AP017558.1 | Halopenitus persicus |
| 82 | 475150 | 475317 | + | NC_013522.1 | Thermanaerovibrio acidaminovorans DSM 6589 |
| 83 | 425154 | 425288 | + | NC_019964.1 | Halovivax ruber XH-70 |
| 84 | 3103925 | 3104089 | + | NC_008212.1 | Haloquadratum walsbyi DSM 16790 |
| 85 | 423424 | 423570 | + | NC_000868.1 | Pyrococcus abyssi GE5 |
| 86 | 472536 | 472694 | + | NZ_CP006965.1 | Thermococcus paralvinellae |
| 87 | 684516 | 684695 | - | NZ_CP039139.1 | Haloferax mediterranei ATCC 33500 |
| 88 | 46306 | 46485 | - | NC_013967.1 | Haloferax volcanii DS2 |
| 89 | 46693 | 46872 | - | NZ_CP011947.1 | Haloferax gibbonsii |
| 90 | 124670 | 124849 | - | NZ_CP048738.1 | Haloferax alexandrinus |
| 91 | 151953 | 152132 | + | NC_014729.1 | Halogeometricum borinquense DSM 11551 |
| 92 | 4202467 | 4202616 | + | NZ_CP026309.1 | Salinigranum rubrum |
| 93 | 7244318 | 7244452 | + | NC_013131.1 | Catenulispora acidiphila DSM 44928 |
| 94 | 2598333 | 2598497 | - | NC_012029.1 | Halorubrum lacusprofundi ATCC 49239 |
| 95 | 107315 | 107491 | + | NZ_CP006867.1 | Ignicoccus islandicus DSM 13165 |
| 96 | 204810 | 204995 | - | NC_014297.1 | Halalkalicoccus jeotgali B3 |
| 97 | 240790 | 240972 | - | NC_020388.1 | Natronomonas moolapensis 8.8.11 |
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| Neighborhood Conservation Analysis |
* Arrows marked in Genome Diagram shows ORFs; Multiple PFAMs can be mapped to a single ORF.
* 'Small ORF' represents the entry/query analyzed.
* Image generated using 'gggenes'(R-Package).
Neighborhood Representative Chosen(Species): NZ_LN999010.1
| Sr.No. | Domain | Co-occurrence Frequency | No. of species in which domain occurs with smORF | Median distance b/w smORF and domain bearing ORFs | Orientation relative to smORF | PFAM Information |
|---|---|---|---|---|---|---|
| 1 | PF00696.30 | 0.73 | 70 | 1982.0 | same-strand | Amino acid kinase family |
| 2 | PF01118.26 | 0.79 | 76 | 919 | same-strand | Semialdehyde dehydrogenase, NAD binding domain |
| 3 | PF08443.13 | 0.92 | 88 | 33 | same-strand | RimK-like ATP-grasp domain |
| 4 | PF02655.16 | 0.77 | 74 | 30.0 | same-strand | ATP-grasp domain |
| 5 | PF00202.23 | 0.6 | 58 | 2859 | same-strand | Aminotransferase class-III |
| 6 | PF01546.30 | 0.61 | 59 | 3991.0 | same-strand | Peptidase family M20/M25/M40 |
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