Protein Information |
Information Type | Description |
---|---|
Protein name | Antitoxin MazE6 |
NCBI Accession ID | AL123456.3 |
Organism | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Left | 2234643 |
Right | 2234891 |
Strand | - |
Nucleotide Sequence | ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTCCGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTCTAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGATGAGTGGTGA |
Sequence | MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDDEW |
Source of smORF | Swiss-Prot |
Function | Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis counteracts the ribonuclease activity of cognate toxin MazF6. {ECO:0000269|Pubmed:17623030, ECO:0000269|Pubmed:18258191, ECO:0000269|Pubmed:19016878, ECO:0000269|Pubmed:20011113, ECO:0000269|Pubmed:20876537}. |
Pubmed ID | 9634230 15718296 16611633 17623030 18258191 19016878 20011113 20876537 21969609 25608501 |
Domain | CDD:425357 |
Functional Category | Antitoxin_type_2_and_DNA-binding |
Uniprot ID | P9WJ87 |
ORF Length (Amino Acid) | 82 |
Conservation Analysis |
Sr.No. | Left Position | Right Position | Strand | NCBI Accession id | Species Name |
---|---|---|---|---|---|
1 | 2234643 | 2234891 | - | NC_000962.3 | Mycobacterium tuberculosis H37Rv |
2 | 2281803 | 2282051 | - | NC_015848.1 | Mycobacterium canettii CIPT 140010059 |
3 | 3112578 | 3112826 | - | NZ_AP022575.1 | Mycobacterium shinjukuense |
4 | 41791 | 42051 | + | NZ_CP025547.1 | Mycobacterium paragordonae |
5 | 2005060 | 2005308 | + | NZ_AP022570.1 | Mycolicibacterium poriferae |
6 | 921401 | 921649 | + | NZ_AP022615.1 | Mycobacterium heidelbergense |
Neighborhood Conservation Analysis |
Sr.No. | Domain | Co-occurrence Frequency | No. of species in which domain occurs with smORF | Median distance b/w smORF and domain bearing ORFs | Orientation relative to smORF | PFAM Information |
---|---|---|---|---|---|---|
1 | PF02452.19 | 0.83 | 5 | -4.5 | same-strand | PemK-like, MazF-like toxin of type II toxin-antitoxin system |