Result : P96621
| Protein Information |
| Information Type | Description |
|---|---|
| Protein name | Antitoxin EndoAI (Antitoxin MazE-bs) (MazE-bs) (EndoA inhibitor) |
| NCBI Accession ID | AB001488.1 |
| Organism | Bacillus subtilis (strain 168) |
| Left | 51720 |
| Right | 52001 |
| Strand | + |
| Nucleotide Sequence | TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGATGCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACCGTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGCGAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA |
| Sequence | MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG |
| Source of smORF | Swiss-Prot |
| Function | Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that directly inhibits activity of EndoA in vitro. Upon expression in E.coli counteracts inhibitory effect of endoribonuclease EndoA. The EndoA-EndoAI complex does not seem to bind its own promoter (Pubmed:24120662). {ECO:0000269|Pubmed:15882409, ECO:0000269|Pubmed:21763692, ECO:0000269|Pubmed:24120662}. |
| Pubmed ID | 9384377 15882409 21763692 24120662 |
| Domain | CDD:419885 |
| Functional Category | Antitoxin_type_2 |
| Uniprot ID | P96621 |
| ORF Length (Amino Acid) | 93 |
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| Conservation Analysis |
No. of Species: 107
| Sr.No. | Left Position | Right Position | Strand | NCBI Accession id | Species Name |
|---|---|---|---|---|---|
| 1 | 674736 | 675017 | + | NZ_CP033052.1 | Bacillus vallismortis |
| 2 | 518490 | 518771 | + | NZ_CP051464.1 | Bacillus mojavensis |
| 3 | 517003 | 517284 | + | NZ_CP034943.1 | Bacillus subtilis subsp. spizizenii ATCC 6633 = JCM 2499 |
| 4 | 471721 | 472002 | + | NZ_CP013984.1 | Bacillus inaquosorum |
| 5 | 1490746 | 1491027 | - | NZ_CP029364.1 | Bacillus halotolerans |
| 6 | 518657 | 518938 | + | NC_000964.3 | Bacillus subtilis subsp. subtilis str. 168 |
| 7 | 495817 | 496098 | + | NZ_CP048852.1 | Bacillus tequilensis |
| 8 | 509033 | 509314 | + | NZ_CP053376.1 | Bacillus amyloliquefaciens |
| 9 | 3440888 | 3441169 | - | NZ_CP011937.1 | Bacillus velezensis |
| 10 | 605362 | 605643 | + | NZ_LT603683.1 | Bacillus glycinifermentans |
| 11 | 559382 | 559663 | + | NC_006270.3 | Bacillus licheniformis DSM 13 = ATCC 14580 |
| 12 | 616472 | 616753 | + | NZ_CP023665.1 | Bacillus paralicheniformis |
| 13 | 1097295 | 1097576 | - | NZ_CP017786.1 | Bacillus xiamenensis |
| 14 | 515551 | 515832 | + | NZ_CP011150.1 | Bacillus altitudinis |
| 15 | 1019526 | 1019807 | - | NZ_CP043404.1 | Bacillus safensis |
| 16 | 4816075 | 4816356 | + | NZ_CP018866.1 | Sutcliffiella cohnii |
| 17 | 3948459 | 3948740 | - | NZ_CP016020.1 | Bacillus weihaiensis |
| 18 | 195323 | 195604 | + | NZ_CP012152.1 | Anoxybacillus gonensis |
| 19 | 59800 | 60081 | + | NZ_CP015440.1 | Anoxybacillus amylolyticus |
| 20 | 1398576 | 1398857 | + | NZ_CP017703.1 | Aeribacillus pallidus |
| 21 | 3008661 | 3008942 | - | NZ_CP014342.1 | Geobacillus subterraneus |
| 22 | 621386 | 621667 | + | NZ_CP042593.1 | Bacillus dafuensis |
| 23 | 1570439 | 1570720 | - | NZ_CP022983.1 | Cytobacillus kochii |
| 24 | 200568 | 200849 | + | NZ_CP024035.1 | Priestia aryabhattai |
| 25 | 542107 | 542388 | + | NZ_CP053989.1 | Niallia circulans |
| 26 | 1390127 | 1390408 | - | NZ_CP041305.1 | Cytobacillus ciccensis |
| 27 | 262155 | 262436 | - | NZ_CP070511.1 | Parageobacillus toebii |
| 28 | 894791 | 895072 | + | NZ_CP016622.1 | Parageobacillus thermoglucosidasius |
| 29 | 3400949 | 3401230 | + | NZ_CP064060.1 | Anoxybacillus caldiproteolyticus |
| 30 | 3070205 | 3070486 | - | NZ_CP012024.1 | Bacillus smithii |
| 31 | 3965475 | 3965756 | - | NZ_CP065425.1 | Heyndrickxia vini |
| 32 | 48117 | 48398 | - | NZ_CP018058.1 | Geobacillus thermocatenulatus |
| 33 | 633739 | 634020 | + | NZ_CP023704.1 | Caldibacillus thermoamylovorans |
| 34 | 243902 | 244183 | + | NC_006510.1 | Geobacillus kaustophilus HTA426 |
| 35 | 2928218 | 2928499 | + | NZ_CP061470.1 | Geobacillus zalihae |
| 36 | 2670130 | 2670411 | + | NZ_CP061472.1 | Geobacillus thermoleovorans |
| 37 | 257658 | 257939 | + | NC_022524.1 | Bacillus infantis NRRL B-14911 |
| 38 | 735908 | 736189 | + | NZ_LS483476.1 | Lederbergia lentus |
| 39 | 1927584 | 1927811 | - | NZ_CP009709.1 | Weizmannia coagulans DSM 1 = ATCC 7050 |
| 40 | 2010261 | 2010488 | + | NZ_CP013023.1 | Paenibacillus bovis |
| 41 | 2995436 | 2995678 | + | NZ_CP011388.1 | Paenibacillus swuensis |
| 42 | 4878387 | 4878674 | - | NZ_CP040336.1 | Bacillus luti |
| 43 | 241188 | 241475 | + | NC_007530.2 | Bacillus anthracis str. 'Ames Ancestor' |
| 44 | 238299 | 238586 | + | NZ_CP064875.1 | Bacillus toyonensis |
| 45 | 239691 | 239978 | + | NC_011725.1 | Bacillus cereus B4264 |
| 46 | 244409 | 244696 | + | NZ_CP032365.1 | Bacillus wiedmannii |
| 47 | 251309 | 251596 | + | NZ_CP024109.1 | Bacillus cytotoxicus |
| 48 | 729184 | 729465 | + | NZ_CP009416.1 | Jeotgalibacillus malaysiensis |
| 49 | 4360009 | 4360260 | - | NZ_CP045293.1 | Paenibacillus guangzhouensis |
| 50 | 4425622 | 4425849 | + | NZ_CP016809.1 | Paenibacillus ihbetae |
| 51 | 2519259 | 2519540 | - | NZ_CP068053.1 | Peribacillus psychrosaccharolyticus |
| 52 | 478553 | 478804 | + | NZ_CP019659.1 | Paenibacillus larvae subsp. larvae |
| 53 | 677489 | 677719 | + | NC_017672.3 | Paenibacillus mucilaginosus K02 |
| 54 | 759430 | 759657 | - | NZ_CP011058.1 | Paenibacillus beijingensis |
| 55 | 486157 | 486399 | + | NZ_CP014167.1 | Paenibacillus yonginensis |
| 56 | 2735967 | 2736248 | + | NZ_CP030926.1 | Peribacillus butanolivorans |
| 57 | 2288806 | 2289087 | - | NZ_CP017704.1 | Peribacillus simplex NBRC 15720 = DSM 1321 |
| 58 | 194433 | 194684 | + | NZ_CP024955.1 | Kyrpidia spormannii |
| 59 | 198664 | 198915 | + | NC_014098.1 | Kyrpidia tusciae DSM 2912 |
| 60 | 5718758 | 5719036 | - | NZ_LR134338.1 | Brevibacillus brevis |
| 61 | 3798391 | 3798621 | - | NZ_CP013652.1 | Paenibacillus naphthalenovorans |
| 62 | 3367025 | 3367252 | + | NZ_CP048429.1 | Paenibacillus jilunlii |
| 63 | 1463492 | 1463719 | + | NZ_CP009287.1 | Paenibacillus graminis |
| 64 | 3303810 | 3304037 | + | NZ_CP068595.1 | Paenibacillus sonchi |
| 65 | 1568413 | 1568640 | + | NZ_LN831776.1 | Paenibacillus riograndensis SBR5 |
| 66 | 5264251 | 5264478 | + | NZ_CP054614.1 | Paenibacillus barcinonensis |
| 67 | 4709763 | 4709990 | + | NZ_CP045295.1 | Paenibacillus cellulositrophicus |
| 68 | 2212600 | 2212827 | + | NZ_CP034248.1 | Paenibacillus lentus |
| 69 | 1469414 | 1469656 | + | NZ_CP009285.1 | Paenibacillus borealis |
| 70 | 4964326 | 4964577 | - | NZ_CP034346.1 | Paenibacillus lutimineralis |
| 71 | 3057908 | 3058138 | - | NC_019897.1 | Thermobacillus composti KWC4 |
| 72 | 5330231 | 5330461 | - | NZ_CP026363.1 | Brevibacillus agri |
| 73 | 777 | 1007 | - | NZ_CP026363.1 | Brevibacillus agri |
| 74 | 397393 | 397674 | + | NC_017668.1 | Halobacillus halophilus DSM 2266 |
| 75 | 2363996 | 2364226 | - | NZ_CP035492.1 | Paenibacillus protaetiae |
| 76 | 1278692 | 1278919 | + | NZ_CP004078.1 | Paenibacillus sabinae T27 |
| 77 | 1481482 | 1481709 | + | NZ_CP009288.1 | Paenibacillus durus |
| 78 | 1243633 | 1243860 | + | NZ_CP009428.1 | Paenibacillus odorifer |
| 79 | 99558 | 99785 | + | NZ_CP021780.1 | Paenibacillus donghaensis |
| 80 | 3256818 | 3257060 | - | NZ_CP033433.1 | Cohnella candidum |
| 81 | 1142532 | 1142774 | + | NZ_CP026520.1 | Paenibacillus chitinolyticus |
| 82 | 1362734 | 1362961 | + | NZ_CP009286.1 | Paenibacillus stellifer |
| 83 | 5317387 | 5317614 | - | NZ_CP043611.1 | Paenibacillus antarcticus |
| 84 | 3741389 | 3741616 | + | NZ_CP045298.1 | Paenibacillus brasilensis |
| 85 | 4206415 | 4206642 | - | NZ_CP020028.1 | Paenibacillus kribbensis |
| 86 | 3110320 | 3110547 | + | NC_016641.1 | Paenibacillus terrae HPL-003 |
| 87 | 5729538 | 5729768 | - | NZ_CP048209.1 | Paenibacillus lycopersici |
| 88 | 6347119 | 6347349 | - | NZ_CP034437.1 | Paenibacillus albus |
| 89 | 4762720 | 4762950 | + | NZ_CP048286.1 | Paenibacillus rhizovicinus |
| 90 | 6183885 | 6184112 | - | NZ_CP034235.1 | Paenibacillus psychroresistens |
| 91 | 1548987 | 1549217 | + | NZ_AP019400.1 | Cohnella abietis |
| 92 | 6748399 | 6748629 | + | NZ_AP019308.1 | Paenibacillus baekrokdamisoli |
| 93 | 244410 | 244661 | + | NZ_CP034118.1 | Staphylospora marina |
| 94 | 4079176 | 4079427 | - | NZ_AP017312.1 | Aneurinibacillus soli |
| 95 | 2551150 | 2551428 | + | NZ_CP017705.1 | Brevibacillus laterosporus DSM 25 |
| 96 | 2604352 | 2604582 | - | NZ_CP039710.1 | Thermoactinomyces vulgaris |
| 97 | 218244 | 218498 | + | NZ_CP015378.1 | Fictibacillus phosphorivorans |
| 98 | 2921854 | 2922084 | - | NZ_CP048104.1 | Kroppenstedtia pulmonis |
| 99 | 2882524 | 2882802 | - | NZ_AP021853.1 | Sporolactobacillus terrae |
| 100 | 549122 | 549400 | + | NC_002570.2 | Alkalihalobacillus halodurans C-125 |
| 101 | 3880487 | 3880768 | - | NZ_CP020772.1 | Halobacillus mangrovi |
| 102 | 442112 | 442387 | + | NZ_CP029797.1 | Paraliobacillus zengyii |
| 103 | 324528 | 324758 | + | NZ_CP048103.1 | Kroppenstedtia eburnea |
| 104 | 444024 | 444305 | + | NZ_CP041666.1 | Radiobacillus deserti |
| 105 | 307932 | 308174 | + | NZ_CP019699.1 | Novibacillus thermophilus |
| 106 | 4045391 | 4045618 | - | NZ_CP022657.1 | Tumebacillus algifaecis |
| 107 | 2066365 | 2066592 | + | NZ_CP021434.1 | Tumebacillus avium |
| 108 | 363882 | 364157 | + | NC_014829.1 | Evansella cellulosilytica DSM 2522 |
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| Neighborhood Conservation Analysis |
* Arrows marked in Genome Diagram shows ORFs; Multiple PFAMs can be mapped to a single ORF.
* 'Small ORF' represents the entry/query analyzed.
* Image generated using 'gggenes'(R-Package).
Neighborhood Representative Chosen(Species): NZ_CP033052.1
| Sr.No. | Domain | Co-occurrence Frequency | No. of species in which domain occurs with smORF | Median distance b/w smORF and domain bearing ORFs | Orientation relative to smORF | PFAM Information |
|---|---|---|---|---|---|---|
| 1 | PF01168.22 | 0.97 | 104 | 218 | same-strand | Alanine racemase, N-terminal domain |
| 2 | PF00842.23 | 0.97 | 104 | 218 | same-strand | Alanine racemase, C-terminal domain |
| 3 | PF02452.19 | 0.88 | 94 | 5.0 | same-strand | PemK-like, MazF-like toxin of type II toxin-antitoxin system |
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