Result : P62553
| Protein Information |
| Information Type | Description |
|---|---|
| Protein name | Antitoxin CcdA (LynA) (Protein H) (Protein LetA) |
| NCBI Accession ID | AF074613.1 |
| Organism | Escherichia coli O157:H7 |
| Left | 51892 |
| Right | 52110 |
| Strand | + |
| Nucleotide Sequence | ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCTGGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTGAGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA |
| Sequence | MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW |
| Source of smORF | Swiss-Prot |
| Function | Antitoxin component of a type II toxin-antitoxin (TA) system which inhibits the post-segregational killing (PSK) of plasmid-free cells, also referred to as a plasmid addiction system. Binds to and blocks the activity of CcdB; will also remove bound CcdB protein from the CcdB-GyrA complex by forming a CcdA-CcdB complex, a process termed rejuvenation. Functions as a transcriptional corepressor for the ccdAB operon, repression also requires CcdB (By similarity). {ECO:0000250}. |
| Pubmed ID | 9722640 9628576 |
| Domain | CDD:413231 |
| Functional Category | Antitoxin_type_2_and_DNA-binding |
| Uniprot ID | P62553 |
| ORF Length (Amino Acid) | 72 |
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| Conservation Analysis |
No. of Species: 28
| Sr.No. | Left Position | Right Position | Strand | NCBI Accession id | Species Name |
|---|---|---|---|---|---|
| 1 | 28682 | 28900 | + | NC_002128.1 | Escherichia coli O157:H7 str. Sakai |
| 2 | 34837 | 35055 | + | NC_013717.1 | Citrobacter rodentium ICC168 |
| 3 | 20096 | 20314 | + | NC_003277.2 | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
| 4 | 20969 | 21187 | - | NZ_CP026048.1 | Raoultella planticola |
| 5 | 14228 | 14446 | - | NZ_CP041250.1 | Raoultella electrica |
| 6 | 180540 | 180758 | + | NC_004851.1 | Shigella flexneri 2a str. 301 |
| 7 | 3968699 | 3968917 | - | NZ_CP065640.1 | Serratia rubidaea |
| 8 | 2674957 | 2675175 | + | NZ_CP040428.1 | Jejubacter calystegiae |
| 9 | 981703 | 981921 | - | NZ_CP031560.1 | Dickeya dianthicola |
| 10 | 3643359 | 3643577 | + | NC_012880.1 | Musicola paradisiaca Ech703 |
| 11 | 3990809 | 3991027 | + | NC_012880.1 | Musicola paradisiaca Ech703 |
| 12 | 3535780 | 3535998 | + | NC_012880.1 | Musicola paradisiaca Ech703 |
| 13 | 4316122 | 4316340 | + | NZ_CP065044.1 | Pectobacterium aroidearum |
| 14 | 3952030 | 3952248 | + | NZ_CP065044.1 | Pectobacterium aroidearum |
| 15 | 354887 | 355105 | - | NZ_CP015749.1 | Pectobacterium parmentieri |
| 16 | 3136690 | 3136908 | + | NZ_CP014137.1 | Brenneria goodwinii |
| 17 | 2758808 | 2759026 | - | NZ_CP015137.1 | Dickeya solani IPO 2222 |
| 18 | 584149 | 584367 | - | NZ_CP025799.1 | Dickeya zeae |
| 19 | 431771 | 431989 | - | NZ_CP034035.1 | Brenneria rubrifaciens |
| 20 | 3807478 | 3807696 | + | NZ_CP034036.1 | Brenneria nigrifluens DSM 30175 = ATCC 13028 |
| 21 | 592379 | 592597 | - | NC_014500.1 | Dickeya dadantii 3937 |
| 22 | 4020431 | 4020649 | + | NC_012912.1 | Dickeya chrysanthemi Ech1591 |
| 23 | 3760206 | 3760424 | + | NZ_CP042220.2 | Dickeya poaceiphila |
| 24 | 4234217 | 4234435 | + | NZ_CP060401.1 | Xenorhabdus nematophila |
| 25 | 5020966 | 5021184 | + | NC_005126.1 | Photorhabdus laumondii subsp. laumondii TTO1 |
| 26 | 606597 | 606824 | + | NZ_CP047495.1 | Pectobacterium brasiliense |
| 27 | 1218290 | 1218508 | + | NZ_CP072455.1 | Xenorhabdus budapestensis |
| 28 | 4889570 | 4889788 | - | NZ_CP017482.1 | Pectobacterium polaris |
| 29 | 4895739 | 4895960 | - | NZ_CP017482.1 | Pectobacterium polaris |
| 30 | 2413087 | 2413305 | - | NZ_CP015750.1 | Pectobacterium wasabiae CFBP 3304 |
| 31 | 3774951 | 3775169 | + | NZ_CP051652.1 | Pectobacterium carotovorum |
| 32 | 579267 | 579485 | - | NZ_CP009125.1 | Pectobacterium atrosepticum |
| 33 | 974187 | 974405 | - | NZ_CP009125.1 | Pectobacterium atrosepticum |
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| Neighborhood Conservation Analysis |
* Arrows marked in Genome Diagram shows ORFs; Multiple PFAMs can be mapped to a single ORF.
* 'Small ORF' represents the entry/query analyzed.
* Image generated using 'gggenes'(R-Package).
Neighborhood Representative Chosen(Species): NC_002128.1
| Sr.No. | Domain | Co-occurrence Frequency | No. of species in which domain occurs with smORF | Median distance b/w smORF and domain bearing ORFs | Orientation relative to smORF | PFAM Information |
|---|---|---|---|---|---|---|
| 1 | PF01845.19 | 0.79 | 22 | 3.0 | same-strand | CcdB protein |
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