Result : P0ADG3
| Protein Information |
| Information Type | Description |
|---|---|
| Protein name | Acetolactate synthase isozyme 2 small subunit (EC 2.2.1.6) (ALS-II) (Acetohydroxy-acid synthase II small subunit) (AHAS-II) |
| NCBI Accession ID | |
| Organism | Shigella flexneri |
| Left | |
| Right | |
| Strand | |
| Nucleotide Sequence | |
| Sequence | MMQHQVNVSARFNPETLERVLRVVRHRGFHVCSMNMAAASDAQNINIELTVASPRSVDLLFSQLNKLVDVAHVAICQSTTTSQQIRA |
| Source of smORF | Swiss-Prot |
| Function | The ORF matches to the profile of cl09141. Profile Description: ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme. The ACT domain is a structural motif of 70-90 amino acids that functions in the control of metabolism, solute transport and signal transduction. They are thus found in a variety of different proteins in a variety of different arrangements. In mammalian phenylalanine hydroxylase the domain forms no contacts but promotes an allosteric effect despite the apparent lack of ligand binding. |
| Pubmed ID | 12384590 12704152 |
| Domain | CDD:415594 |
| Functional Category | Others |
| Uniprot ID | P0ADG3 |
| ORF Length (Amino Acid) | 87 |
++ More..
| Conservation Analysis |
No. of Species: 157
| Sr.No. | Left Position | Right Position | Strand | NCBI Accession id | Species Name |
|---|---|---|---|---|---|
| 1 | 4281198 | 4281461 | + | NZ_CP061527.1 | Shigella dysenteriae |
| 2 | 4391844 | 4392107 | - | NZ_LR134340.1 | Escherichia marmotae |
| 3 | 2821777 | 2822040 | - | NZ_CP057657.1 | Escherichia fergusonii |
| 4 | 3961643 | 3961906 | + | NC_004337.2 | Shigella flexneri 2a str. 301 |
| 5 | 3952201 | 3952464 | + | NC_000913.3 | Escherichia coli str. K-12 substr. MG1655 |
| 6 | 4745773 | 4746036 | + | NC_002695.2 | Escherichia coli O157:H7 str. Sakai |
| 7 | 3919323 | 3919586 | + | NZ_AP014857.1 | Escherichia albertii |
| 8 | 104189 | 104452 | + | NC_009792.1 | Citrobacter koseri ATCC BAA-895 |
| 9 | 3369151 | 3369414 | - | NZ_CP038469.1 | Citrobacter tructae |
| 10 | 2362534 | 2362797 | - | NZ_CP044098.1 | Citrobacter portucalensis |
| 11 | 2727484 | 2727747 | + | NZ_CP033744.1 | Citrobacter freundii |
| 12 | 4110629 | 4110892 | + | NC_003197.2 | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
| 13 | 4206166 | 4206429 | - | NC_013716.1 | Citrobacter rodentium ICC168 |
| 14 | 1158381 | 1158644 | - | NZ_LT556085.1 | Citrobacter amalonaticus |
| 15 | 1916122 | 1916385 | + | NZ_CP053416.1 | Salmonella bongori |
| 16 | 2758983 | 2759246 | + | NZ_CP025034.2 | Enterobacter sp. SGAir0187 |
| 17 | 3760328 | 3760591 | + | NZ_CP045769.1 | Enterobacter cancerogenus |
| 18 | 13240 | 13503 | + | NZ_CP017280.1 | Enterobacter ludwigii |
| 19 | 2624463 | 2624726 | + | NZ_AP019007.1 | Enterobacter oligotrophicus |
| 20 | 3307766 | 3308029 | - | NZ_CP023529.1 | Lelliottia amnigena |
| 21 | 514137 | 514400 | + | NZ_CP045205.1 | Citrobacter telavivensis |
| 22 | 4457576 | 4457839 | - | NZ_AP022508.1 | Enterobacter bugandensis |
| 23 | 4556887 | 4557150 | - | NZ_CP027986.1 | Enterobacter sichuanensis |
| 24 | 4557269 | 4557532 | - | NZ_CP017184.1 | Enterobacter roggenkampii |
| 25 | 4676509 | 4676772 | - | NZ_CP009756.1 | Enterobacter cloacae |
| 26 | 4910914 | 4911177 | - | NZ_CP043318.1 | Enterobacter chengduensis |
| 27 | 4614964 | 4615227 | - | NC_015968.1 | Enterobacter soli |
| 28 | 286691 | 286954 | - | NZ_CP051548.1 | Phytobacter diazotrophicus |
| 29 | 4407495 | 4407758 | - | NZ_CP011602.1 | Phytobacter ursingii |
| 30 | 727061 | 727324 | - | NZ_CP020388.1 | Pluralibacter gergoviae |
| 31 | 4418576 | 4418839 | - | NZ_CP054058.1 | Scandinavium goeteborgense |
| 32 | 2994963 | 2995232 | - | NZ_CP045300.1 | Kosakonia arachidis |
| 33 | 5241711 | 5241980 | - | NZ_CP014007.2 | Kosakonia oryzae |
| 34 | 5484973 | 5485242 | + | NZ_CP015113.1 | Kosakonia radicincitans |
| 35 | 3294333 | 3294602 | + | NZ_CP016337.1 | Kosakonia sacchari |
| 36 | 141191 | 141460 | + | NZ_CP063425.1 | Kosakonia pseudosacchari |
| 37 | 131137 | 131394 | + | NC_016845.1 | Klebsiella pneumoniae subsp. pneumoniae HS11286 |
| 38 | 118881 | 119150 | + | NZ_CP012871.1 | [Enterobacter] lignolyticus |
| 39 | 4522965 | 4523231 | - | NZ_CP045845.1 | Kluyvera intermedia |
| 40 | 5078141 | 5078398 | - | NZ_CP065838.1 | Klebsiella quasipneumoniae |
| 41 | 174265 | 174534 | + | NZ_CP013990.1 | Leclercia adecarboxylata |
| 42 | 5370419 | 5370676 | - | NZ_CP054254.1 | Klebsiella variicola |
| 43 | 5128953 | 5129210 | - | NZ_LR134475.1 | Klebsiella aerogenes |
| 44 | 4524477 | 4524743 | - | NZ_CP035129.1 | Kosakonia cowanii |
| 45 | 3189751 | 3190008 | - | NZ_CP027107.1 | Cronobacter sakazakii |
| 46 | 3789450 | 3789707 | - | NZ_CP012268.1 | Cronobacter muytjensii ATCC 51329 |
| 47 | 254704 | 254961 | + | NZ_CP012266.1 | Cronobacter dublinensis subsp. dublinensis LMG 23823 |
| 48 | 1896907 | 1897164 | + | NZ_CP026047.1 | Raoultella planticola |
| 49 | 5412984 | 5413241 | - | NZ_CP046672.1 | Raoultella ornithinolytica |
| 50 | 1530491 | 1530760 | - | NZ_CP042941.1 | Atlantibacter hermannii |
| 51 | 5114547 | 5114804 | - | NZ_CP041247.1 | Raoultella electrica |
| 52 | 1414489 | 1414746 | + | NZ_CP040428.1 | Jejubacter calystegiae |
| 53 | 5998606 | 5998863 | - | NZ_CP060111.1 | Klebsiella michiganensis |
| 54 | 260648 | 260911 | + | NZ_CP012264.1 | Cronobacter condimenti 1330 |
| 55 | 5977307 | 5977564 | - | NZ_CP036175.1 | Klebsiella huaxiensis |
| 56 | 4896527 | 4896784 | - | NZ_CP023525.1 | Cedecea neteri |
| 57 | 5435425 | 5435682 | - | NZ_CP050508.1 | Raoultella terrigena |
| 58 | 4472607 | 4472864 | - | NZ_LR134201.1 | Cedecea lapagei |
| 59 | 1305130 | 1305396 | - | NZ_CP065640.1 | Serratia rubidaea |
| 60 | 1152065 | 1152322 | + | NZ_CP007044.2 | Chania multitudinisentens RB-25 |
| 61 | 5162392 | 5162649 | - | NZ_LR134494.1 | Serratia quinivorans |
| 62 | 2722751 | 2723008 | + | NZ_CP014136.1 | Gibbsiella quercinecans |
| 63 | 5070597 | 5070854 | - | NZ_CP038662.1 | Serratia nematodiphila |
| 64 | 189835 | 190092 | + | NZ_CP012257.1 | Cronobacter universalis NCTC 9529 |
| 65 | 122322 | 122579 | + | NZ_CP071320.1 | Serratia ureilytica |
| 66 | 5246230 | 5246487 | - | NC_015567.1 | Serratia plymuthica AS9 |
| 67 | 4282796 | 4283053 | - | NZ_CP016948.1 | Serratia surfactantfaciens |
| 68 | 3949019 | 3949282 | - | NC_017910.1 | Shimwellia blattae DSM 4481 = NBRC 105725 |
| 69 | 5018234 | 5018491 | - | NZ_LT906479.1 | Serratia ficaria |
| 70 | 2088979 | 2089236 | - | NZ_CP011078.1 | Yersinia ruckeri |
| 71 | 3457874 | 3458137 | - | NZ_CP067057.1 | Rahnella aceris |
| 72 | 3057692 | 3057949 | + | NZ_CP009787.1 | Yersinia rohdei |
| 73 | 165394 | 165651 | + | NZ_CP043727.1 | Yersinia canariae |
| 74 | 168619 | 168876 | + | NZ_CP032487.1 | Yersinia hibernica |
| 75 | 1792962 | 1793219 | + | NZ_CP007230.1 | Yersinia similis |
| 76 | 4514377 | 4514634 | - | NZ_CP011118.1 | Yersinia enterocolitica |
| 77 | 4406429 | 4406686 | - | NZ_LR134373.1 | Yersinia pseudotuberculosis |
| 78 | 3500320 | 3500577 | - | NZ_CP028271.1 | Mixta intestinalis |
| 79 | 3912530 | 3912787 | - | NZ_CP013940.1 | Cronobacter malonaticus LMG 23826 |
| 80 | 1036013 | 1036270 | - | NZ_CP054043.1 | Yersinia mollaretii ATCC 43969 |
| 81 | 4357128 | 4357385 | - | NZ_AP023184.1 | Buttiauxella agrestis |
| 82 | 3849711 | 3849968 | - | NZ_CP034148.1 | Pantoea agglomerans |
| 83 | 218112 | 218369 | + | NZ_CP045720.1 | Pantoea eucalypti |
| 84 | 231708 | 231965 | + | NZ_CP038853.1 | Pantoea vagans |
| 85 | 4516418 | 4516630 | - | NZ_CP046293.1 | Yersinia intermedia |
| 86 | 2512591 | 2512803 | - | NZ_CP009781.1 | Yersinia aldovae 670-83 |
| 87 | 2684536 | 2684793 | - | NZ_CP049115.1 | Pantoea stewartii |
| 88 | 244508 | 244768 | + | NZ_CP051652.1 | Pectobacterium carotovorum |
| 89 | 256707 | 256967 | + | NZ_CP065044.1 | Pectobacterium aroidearum |
| 90 | 312830 | 313087 | + | NZ_CP006569.1 | Sodalis praecaptivus |
| 91 | 208088 | 208345 | + | NC_014306.1 | Erwinia billingiae Eb661 |
| 92 | 216090 | 216350 | + | NZ_CP038498.1 | Pectobacterium punjabense |
| 93 | 3446402 | 3446662 | - | NZ_CP017482.1 | Pectobacterium polaris |
| 94 | 1540459 | 1540716 | - | NZ_CP011254.1 | Serratia fonticola |
| 95 | 234195 | 234452 | + | NC_017554.1 | Pantoea ananatis PA13 |
| 96 | 1904734 | 1904994 | + | NZ_CP047495.1 | Pectobacterium brasiliense |
| 97 | 4482715 | 4482975 | + | NZ_CP015749.1 | Pectobacterium parmentieri |
| 98 | 1388891 | 1389151 | - | NZ_CP015750.1 | Pectobacterium wasabiae CFBP 3304 |
| 99 | 4632735 | 4632995 | - | NZ_CP034938.1 | Pectobacterium odoriferum |
| 100 | 4837810 | 4838067 | - | NC_012962.1 | Photorhabdus asymbiotica |
| 101 | 4636481 | 4636741 | - | NZ_CP009125.1 | Pectobacterium atrosepticum |
| 102 | 5106493 | 5106750 | - | NZ_CP048784.1 | Serratia liquefaciens |
| 103 | 5463013 | 5463270 | - | NC_005126.1 | Photorhabdus laumondii subsp. laumondii TTO1 |
| 104 | 189019 | 189276 | + | NC_013961.1 | Erwinia amylovora CFBP1430 |
| 105 | 4032734 | 4032991 | - | NC_013892.1 | Xenorhabdus bovienii SS-2004 |
| 106 | 3799377 | 3799634 | - | NZ_CP023567.1 | Erwinia pyrifoliae |
| 107 | 1792239 | 1792481 | + | NZ_CP019706.1 | Pantoea alhagi |
| 108 | 222062 | 222319 | + | NC_010694.1 | Erwinia tasmaniensis Et1/99 |
| 109 | 1650619 | 1650876 | - | NZ_CP011104.1 | Photorhabdus thracensis |
| 110 | 3135966 | 3136223 | - | NZ_CP060401.1 | Xenorhabdus nematophila |
| 111 | 152254 | 152511 | + | NZ_LN907827.1 | Erwinia gerundensis |
| 112 | 3131600 | 3131857 | - | NZ_CP016176.1 | Xenorhabdus hominickii |
| 113 | 4595990 | 4596247 | - | NC_014500.1 | Dickeya dadantii 3937 |
| 114 | 1853568 | 1853825 | - | NZ_CP015137.1 | Dickeya solani IPO 2222 |
| 115 | 3645163 | 3645423 | - | NZ_CP034035.1 | Brenneria rubrifaciens |
| 116 | 4380476 | 4380733 | - | NC_012880.1 | Musicola paradisiaca Ech703 |
| 117 | 4157814 | 4158071 | - | NZ_CP072455.1 | Xenorhabdus budapestensis |
| 118 | 179017 | 179259 | + | NZ_CP065534.1 | Lonsdalea populi |
| 119 | 4403965 | 4404222 | - | NZ_CP025799.1 | Dickeya zeae |
| 120 | 4269217 | 4269474 | - | NZ_LT615367.1 | Dickeya aquatica |
| 121 | 295166 | 295423 | + | NZ_CP042220.2 | Dickeya poaceiphila |
| 122 | 4197742 | 4198005 | - | NZ_CP015581.1 | Tatumella citrea |
| 123 | 145065 | 145322 | + | NZ_CP050150.1 | Hafnia alvei |
| 124 | 3113452 | 3113709 | + | NZ_CP009460.1 | Dickeya fangzhongdai |
| 125 | 3713518 | 3713775 | - | NZ_CP029185.2 | Limnobaculum parvum |
| 126 | 3455712 | 3455969 | - | NZ_FO704551.1 | Xenorhabdus poinarii G6 |
| 127 | 167307 | 167564 | + | NC_012912.1 | Dickeya chrysanthemi Ech1591 |
| 128 | 907549 | 907791 | - | NZ_CP023009.1 | Lonsdalea britannica |
| 129 | 4368332 | 4368589 | - | NZ_CP026377.1 | Mixta gaviniae |
| 130 | 266863 | 267126 | + | NZ_CP034036.1 | Brenneria nigrifluens DSM 30175 = ATCC 13028 |
| 131 | 4557334 | 4557597 | + | NZ_CP014137.1 | Brenneria goodwinii |
| 132 | 305213 | 305470 | + | NZ_FO704550.1 | Xenorhabdus doucetiae |
| 133 | 3918336 | 3918593 | - | NZ_LR134531.1 | Pragia fontium |
| 134 | 4618817 | 4619074 | - | NZ_CP031560.1 | Dickeya dianthicola |
| 135 | 273552 | 273809 | + | NZ_CP034752.1 | Jinshanibacter zhutongyuii |
| 136 | 3848738 | 3848995 | - | NZ_LS483470.1 | Leminorella richardii |
| 137 | 1738711 | 1738992 | + | NZ_CP026364.1 | Proteus hauseri |
| 138 | 1004849 | 1005118 | + | NZ_CP029736.1 | Providencia rettgeri |
| 139 | 4063462 | 4063719 | - | NZ_CP061511.1 | Mixta calida |
| 140 | 3533908 | 3534177 | - | NZ_CP031123.2 | Providencia huaxiensis |
| 141 | 169325 | 169600 | + | NZ_CP047349.1 | Proteus terrae subsp. cibarius |
| 142 | 1224090 | 1224359 | + | NZ_CP023536.1 | Providencia alcalifaciens |
| 143 | 4065902 | 4066171 | - | NZ_CP048796.1 | Providencia vermicola |
| 144 | 4071937 | 4072206 | - | NZ_LS483422.1 | Providencia heimbachae |
| 145 | 72276 | 72563 | + | NC_012779.2 | Edwardsiella ictaluri 93-146 |
| 146 | 4052528 | 4052788 | - | NZ_CP012621.1 | Zobellella denitrificans |
| 147 | 3386444 | 3386710 | + | NC_012691.1 | Tolumonas auensis DSM 9187 |
| 148 | 2809758 | 2810015 | + | NZ_CP040021.1 | Salinivibrio kushneri |
| 149 | 3382338 | 3382550 | - | NZ_CP051883.1 | Aeromonas salmonicida |
| 150 | 1603742 | 1603960 | - | NZ_CP023706.1 | Edwardsiella tarda |
| 151 | 3673920 | 3674138 | - | NZ_CP016043.1 | Edwardsiella hoshinae |
| 152 | 113063 | 113311 | + | NZ_LR134376.1 | Aeromonas encheleia |
| 153 | 156713 | 156991 | + | NZ_AP022188.1 | Aeromonas media |
| 154 | 3436295 | 3436573 | + | NZ_CP044060.1 | Aeromonas veronii |
| 155 | 1837585 | 1837872 | + | NZ_CP006664.1 | Edwardsiella anguillarum ET080813 |
| 156 | 3681225 | 3681503 | + | NZ_CP065745.1 | Aeromonas allosaccharophila |
| 157 | 158817 | 159035 | + | NC_011852.1 | Glaesserella parasuis SH0165 |
| 158 | 845392 | 845622 | + | NZ_CP028926.1 | Pasteurella multocida |
++ More..
| Neighborhood Conservation Analysis |
* Arrows marked in Genome Diagram shows ORFs; Multiple PFAMs can be mapped to a single ORF.
* 'Small ORF' represents the entry/query analyzed.
* Image generated using 'gggenes'(R-Package).
Neighborhood Representative Chosen(Species): NZ_LR134340.1
| Sr.No. | Domain | Co-occurrence Frequency | No. of species in which domain occurs with smORF | Median distance b/w smORF and domain bearing ORFs | Orientation relative to smORF | PFAM Information |
|---|---|---|---|---|---|---|
| 1 | PF13335.8 | 0.97 | 153 | 2234.0 | opposite-strand | Magnesium chelatase, subunit ChlI C-terminal |
| 2 | PF01078.23 | 0.97 | 152 | 2234 | opposite-strand | Magnesium chelatase, subunit ChlI |
| 3 | PF07728.16 | 0.97 | 153 | 2234.0 | opposite-strand | AAA domain (dynein-related subfamily) |
| 4 | PF02776.20 | 1.0 | 157 | -3.0 | same-strand | Thiamine pyrophosphate enzyme, N-terminal TPP binding domain |
| 5 | PF02775.23 | 1.0 | 157 | -3.0 | same-strand | Thiamine pyrophosphate enzyme, C-terminal TPP binding domain |
| 6 | PF00205.24 | 1.0 | 157 | -3.0 | same-strand | Thiamine pyrophosphate enzyme, central domain |
| 7 | PF01063.21 | 0.99 | 155 | 20.0 | same-strand | Amino-transferase class IV |
| 8 | PF00920.23 | 0.99 | 156 | 1024 | same-strand | Dehydratase family |
| 9 | PF00291.27 | 0.99 | 156 | 2879 | same-strand | Pyridoxal-phosphate dependent enzyme |
| 10 | PF00585.20 | 0.99 | 156 | 2879 | same-strand | C-terminal regulatory domain of Threonine dehydratase |
| 11 | PF03466.22 | 0.94 | 147 | 4409.5 | opposite-strand | LysR substrate binding domain |
| 12 | PF00126.29 | 0.94 | 147 | 4409.5 | opposite-strand | Bacterial regulatory helix-turn-helix protein, lysR family |
| 13 | PF13541.8 | 0.96 | 151 | 2234.0 | opposite-strand | Subunit ChlI of Mg-chelatase |
| 14 | PF04219.14 | 0.89 | 140 | 3808 | same-strand | Protein of unknown function, DUF |
++ More..