Result : P0ACE3
| Protein Information |
| Information Type | Description |
|---|---|
| Protein name | Hemolysin expression-modulating protein Hha |
| NCBI Accession ID | X57977.1 |
| Organism | Escherichia coli (strain K12) |
| Left | 343 |
| Right | 561 |
| Strand | + |
| Nucleotide Sequence | ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGTTATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAATTGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA |
| Sequence | MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR |
| Source of smORF | Swiss-Prot |
| Function | Down-regulates hemolysin (hly) expression in complex with H-NS (Pubmed:1956303, Pubmed:10778755, Pubmed:11790731, Pubmed:21600204). Stimulates transposition events in vivo (Pubmed:8145648). Modifies the set of genes regulated by H-NS; Hha and Cnu (YdgT) increase the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex (Pubmed:23543115). Binds DNA and influences DNA topology in response to environmental stimuli; does not however interact with DNA in the absence of H-NS (Pubmed:23543115). Involved in persister cell formation, acting downstream of mRNA interferase (toxin) MqsR (Pubmed:19909729). Decreases biofilm formation by repressing the transcription of fimbrial genes fimA and ihfA, and by repressing the transcription of tRNAs corresponding to rare codons, which are abundant in type 1 fimbrial genes (Pubmed:18545668). {ECO:0000269|Pubmed:10778755, ECO:0000269|Pubmed:11790731, ECO:0000269|Pubmed:16317765, ECO:0000269|Pubmed:18545668, ECO:0000269|Pubmed:1956303, ECO:0000269|Pubmed:19909729, ECO:0000269|Pubmed:21600204, ECO:0000269|Pubmed:23543115, ECO:0000269|Pubmed:8145648}. |
| Pubmed ID | 1956303 9278503 16738553 1484495 8145648 10322001 10778755 11790731 14727089 16317765 16650431 18545668 19909729 21600204 23543115 11854485 26085102 |
| Domain | CDD:416300 |
| Functional Category | DNA-binding |
| Uniprot ID | P0ACE3 |
| ORF Length (Amino Acid) | 72 |
++ More..
| Conservation Analysis |
No. of Species: 146
| Sr.No. | Left Position | Right Position | Strand | NCBI Accession id | Species Name |
|---|---|---|---|---|---|
| 1 | 3160432 | 3160650 | - | NZ_CP061527.1 | Shigella dysenteriae |
| 2 | 546156 | 546374 | - | NC_002695.2 | Escherichia coli O157:H7 str. Sakai |
| 3 | 480090 | 480308 | - | NC_000913.3 | Escherichia coli str. K-12 substr. MG1655 |
| 4 | 416621 | 416839 | - | NC_004337.2 | Shigella flexneri 2a str. 301 |
| 5 | 2826432 | 2826650 | - | NZ_CP042941.1 | Atlantibacter hermannii |
| 6 | 498083 | 498301 | - | NZ_AP014857.1 | Escherichia albertii |
| 7 | 1124963 | 1125181 | - | NZ_LR134340.1 | Escherichia marmotae |
| 8 | 3970787 | 3971005 | + | NZ_CP065838.1 | Klebsiella quasipneumoniae |
| 9 | 3059593 | 3059811 | - | NZ_CP053416.1 | Salmonella bongori |
| 10 | 1607707 | 1607925 | + | NZ_CP057657.1 | Escherichia fergusonii |
| 11 | 528134 | 528352 | - | NC_003197.2 | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
| 12 | 2692165 | 2692383 | - | NZ_LT556085.1 | Citrobacter amalonaticus |
| 13 | 2754612 | 2754821 | - | NZ_LT556085.1 | Citrobacter amalonaticus |
| 14 | 4419962 | 4420180 | + | NZ_CP045205.1 | Citrobacter telavivensis |
| 15 | 1240086 | 1240304 | - | NC_016845.1 | Klebsiella pneumoniae subsp. pneumoniae HS11286 |
| 16 | 4238500 | 4238718 | + | NZ_CP054254.1 | Klebsiella variicola |
| 17 | 1177669 | 1177887 | - | NZ_CP012871.1 | [Enterobacter] lignolyticus |
| 18 | 2497865 | 2498083 | + | NC_009792.1 | Citrobacter koseri ATCC BAA-895 |
| 19 | 2166942 | 2167160 | + | NZ_CP038469.1 | Citrobacter tructae |
| 20 | 1130153 | 1130371 | + | NZ_CP044098.1 | Citrobacter portucalensis |
| 21 | 3985448 | 3985666 | - | NZ_CP033744.1 | Citrobacter freundii |
| 22 | 573537 | 573755 | - | NC_013716.1 | Citrobacter rodentium ICC168 |
| 23 | 5232615 | 5232827 | + | NC_013716.1 | Citrobacter rodentium ICC168 |
| 24 | 3959041 | 3959259 | + | NZ_LR134475.1 | Klebsiella aerogenes |
| 25 | 2951683 | 2951901 | + | NC_017910.1 | Shimwellia blattae DSM 4481 = NBRC 105725 |
| 26 | 4018004 | 4018222 | + | NZ_CP041247.1 | Raoultella electrica |
| 27 | 4251584 | 4251802 | + | NZ_CP046672.1 | Raoultella ornithinolytica |
| 28 | 2990367 | 2990585 | - | NZ_CP026047.1 | Raoultella planticola |
| 29 | 3499928 | 3500146 | + | NZ_CP054058.1 | Scandinavium goeteborgense |
| 30 | 2983997 | 2984215 | + | NZ_CP013940.1 | Cronobacter malonaticus LMG 23826 |
| 31 | 3617016 | 3617234 | - | NZ_AP019007.1 | Enterobacter oligotrophicus |
| 32 | 2471471 | 2471689 | + | NZ_CP045769.1 | Enterobacter cancerogenus |
| 33 | 1154167 | 1154385 | - | NZ_CP012264.1 | Cronobacter condimenti 1330 |
| 34 | 2276827 | 2277045 | + | NZ_CP027107.1 | Cronobacter sakazakii |
| 35 | 3691663 | 3691881 | + | NZ_CP013990.1 | Leclercia adecarboxylata |
| 36 | 1159749 | 1159967 | - | NZ_CP012266.1 | Cronobacter dublinensis subsp. dublinensis LMG 23823 |
| 37 | 213959 | 214177 | - | NZ_CP017279.1 | Enterobacter ludwigii |
| 38 | 3447451 | 3447669 | + | NZ_CP045845.1 | Kluyvera intermedia |
| 39 | 1098823 | 1099041 | - | NZ_CP027986.1 | Enterobacter sichuanensis |
| 40 | 2886430 | 2886648 | + | NZ_CP012268.1 | Cronobacter muytjensii ATCC 51329 |
| 41 | 1106075 | 1106293 | - | NZ_AP022508.1 | Enterobacter bugandensis |
| 42 | 1056793 | 1057011 | - | NZ_CP017184.1 | Enterobacter roggenkampii |
| 43 | 1451791 | 1452009 | + | NZ_CP025034.2 | Enterobacter sp. SGAir0187 |
| 44 | 1297021 | 1297239 | - | NZ_CP043318.1 | Enterobacter chengduensis |
| 45 | 2243067 | 2243285 | - | NZ_CP020388.1 | Pluralibacter gergoviae |
| 46 | 2423017 | 2423235 | - | NZ_CP040428.1 | Jejubacter calystegiae |
| 47 | 1863520 | 1863738 | + | NZ_CP045300.1 | Kosakonia arachidis |
| 48 | 4065920 | 4066138 | + | NZ_CP014007.2 | Kosakonia oryzae |
| 49 | 1049069 | 1049287 | - | NZ_CP015113.1 | Kosakonia radicincitans |
| 50 | 1052661 | 1052879 | - | NC_015968.1 | Enterobacter soli |
| 51 | 1149360 | 1149578 | - | NZ_CP012257.1 | Cronobacter universalis NCTC 9529 |
| 52 | 4361849 | 4362067 | + | NZ_CP050508.1 | Raoultella terrigena |
| 53 | 3433583 | 3433801 | + | NZ_AP023184.1 | Buttiauxella agrestis |
| 54 | 1901717 | 1901935 | + | NZ_CP016337.1 | Kosakonia sacchari |
| 55 | 1160324 | 1160542 | - | NZ_CP063425.1 | Kosakonia pseudosacchari |
| 56 | 1131175 | 1131393 | - | NZ_CP009756.1 | Enterobacter cloacae |
| 57 | 4656672 | 4656890 | + | NZ_CP060111.1 | Klebsiella michiganensis |
| 58 | 3468966 | 3469184 | + | NZ_CP035129.1 | Kosakonia cowanii |
| 59 | 6840 | 7058 | - | NZ_CP023529.1 | Lelliottia amnigena |
| 60 | 4602782 | 4603000 | + | NZ_CP051548.1 | Phytobacter diazotrophicus |
| 61 | 3373233 | 3373451 | + | NZ_CP011602.1 | Phytobacter ursingii |
| 62 | 4577336 | 4577554 | + | NZ_CP036175.1 | Klebsiella huaxiensis |
| 63 | 1063102 | 1063284 | - | NZ_LR134201.1 | Cedecea lapagei |
| 64 | 1109993 | 1110175 | - | NZ_CP023525.1 | Cedecea neteri |
| 65 | 1201681 | 1201899 | - | NC_014306.1 | Erwinia billingiae Eb661 |
| 66 | 1093722 | 1093940 | - | NZ_LN907827.1 | Erwinia gerundensis |
| 67 | 2793682 | 2793900 | + | NC_010694.1 | Erwinia tasmaniensis Et1/99 |
| 68 | 1108275 | 1108493 | - | NZ_CP023567.1 | Erwinia pyrifoliae |
| 69 | 1081001 | 1081219 | - | NC_013961.1 | Erwinia amylovora CFBP1430 |
| 70 | 472617 | 472835 | - | NZ_CP028271.1 | Mixta intestinalis |
| 71 | 3937350 | 3937532 | - | NZ_CP049115.1 | Pantoea stewartii |
| 72 | 368312 | 368530 | + | NZ_CP019706.1 | Pantoea alhagi |
| 73 | 1229709 | 1229927 | - | NZ_CP061511.1 | Mixta calida |
| 74 | 1301816 | 1302034 | - | NZ_CP026377.1 | Mixta gaviniae |
| 75 | 3445176 | 3445358 | + | NC_017554.1 | Pantoea ananatis PA13 |
| 76 | 1150435 | 1150653 | - | NZ_CP015581.1 | Tatumella citrea |
| 77 | 1003068 | 1003250 | - | NZ_CP034148.1 | Pantoea agglomerans |
| 78 | 3115244 | 3115426 | + | NZ_CP045720.1 | Pantoea eucalypti |
| 79 | 3050337 | 3050519 | + | NZ_CP038853.1 | Pantoea vagans |
| 80 | 1085506 | 1085709 | - | NZ_CP048784.1 | Serratia liquefaciens |
| 81 | 3931120 | 3931323 | + | NZ_CP071320.1 | Serratia ureilytica |
| 82 | 423612 | 423815 | - | NZ_CP016948.1 | Serratia surfactantfaciens |
| 83 | 1120406 | 1120609 | - | NZ_CP038662.1 | Serratia nematodiphila |
| 84 | 848132 | 848335 | - | NZ_CP048796.1 | Providencia vermicola |
| 85 | 2593497 | 2593700 | - | NZ_CP060401.1 | Xenorhabdus nematophila |
| 86 | 3644715 | 3644918 | + | NZ_CP072455.1 | Xenorhabdus budapestensis |
| 87 | 2338805 | 2339008 | - | NZ_CP026364.1 | Proteus hauseri |
| 88 | 738002 | 738205 | - | NZ_CP047349.1 | Proteus terrae subsp. cibarius |
| 89 | 230922 | 231125 | + | NZ_CP023536.1 | Providencia alcalifaciens |
| 90 | 4303664 | 4303867 | + | NZ_CP029736.1 | Providencia rettgeri |
| 91 | 2447519 | 2447722 | + | NZ_CP016176.1 | Xenorhabdus hominickii |
| 92 | 2639534 | 2639737 | - | NZ_CP065640.1 | Serratia rubidaea |
| 93 | 160608 | 160811 | - | NC_010554.1 | Proteus mirabilis HI4320 |
| 94 | 492203 | 492406 | - | NZ_FO704551.1 | Xenorhabdus poinarii G6 |
| 95 | 1151965 | 1152168 | - | NC_015567.1 | Serratia plymuthica AS9 |
| 96 | 209085 | 209288 | - | NZ_CP031123.2 | Providencia huaxiensis |
| 97 | 872940 | 873143 | - | NZ_FO704550.1 | Xenorhabdus doucetiae |
| 98 | 1218511 | 1218714 | - | NZ_LT906479.1 | Serratia ficaria |
| 99 | 1159051 | 1159254 | - | NZ_LR134494.1 | Serratia quinivorans |
| 100 | 1585337 | 1585540 | + | NC_013892.1 | Xenorhabdus bovienii SS-2004 |
| 101 | 2370387 | 2370590 | + | NZ_CP067057.1 | Rahnella aceris |
| 102 | 3387946 | 3388128 | + | NZ_CP050150.1 | Hafnia alvei |
| 103 | 3945956 | 3946165 | + | NZ_CP050150.1 | Hafnia alvei |
| 104 | 4004476 | 4004679 | + | NC_012962.1 | Photorhabdus asymbiotica |
| 105 | 704057 | 704260 | - | NZ_CP011104.1 | Photorhabdus thracensis |
| 106 | 4527639 | 4527842 | + | NC_005126.1 | Photorhabdus laumondii subsp. laumondii TTO1 |
| 107 | 3248141 | 3248344 | - | NZ_CP011078.1 | Yersinia ruckeri |
| 108 | 3254610 | 3254813 | - | NZ_CP011254.1 | Serratia fonticola |
| 109 | 4863908 | 4864111 | + | NZ_CP007044.2 | Chania multitudinisentens RB-25 |
| 110 | 4185920 | 4186111 | + | NZ_CP007044.2 | Chania multitudinisentens RB-25 |
| 111 | 890249 | 890452 | - | NZ_LS483422.1 | Providencia heimbachae |
| 112 | 4052855 | 4053058 | - | NZ_CP009787.1 | Yersinia rohdei |
| 113 | 3375787 | 3375990 | + | NZ_LR134373.1 | Yersinia pseudotuberculosis |
| 114 | 3433104 | 3433307 | + | NZ_CP043727.1 | Yersinia canariae |
| 115 | 3451452 | 3451655 | + | NZ_CP011118.1 | Yersinia enterocolitica |
| 116 | 2873306 | 2873509 | + | NZ_CP032487.1 | Yersinia hibernica |
| 117 | 2819399 | 2819602 | - | NZ_CP007230.1 | Yersinia similis |
| 118 | 1514885 | 1515088 | + | NZ_CP009781.1 | Yersinia aldovae 670-83 |
| 119 | 3153721 | 3153897 | + | NZ_LT615367.1 | Dickeya aquatica |
| 120 | 1394860 | 1395063 | + | NZ_CP014136.1 | Gibbsiella quercinecans |
| 121 | 1090499 | 1090702 | - | NC_012779.2 | Edwardsiella ictaluri 93-146 |
| 122 | 2967128 | 2967331 | - | NZ_CP006664.1 | Edwardsiella anguillarum ET080813 |
| 123 | 1131544 | 1131747 | - | NZ_CP046293.1 | Yersinia intermedia |
| 124 | 2428254 | 2428457 | - | NZ_CP054043.1 | Yersinia mollaretii ATCC 43969 |
| 125 | 1151294 | 1151497 | - | NC_012880.1 | Musicola paradisiaca Ech703 |
| 126 | 1023763 | 1023966 | - | NZ_CP034035.1 | Brenneria rubrifaciens |
| 127 | 3005948 | 3006151 | + | NZ_CP042220.2 | Dickeya poaceiphila |
| 128 | 1218470 | 1218673 | - | NZ_CP025799.1 | Dickeya zeae |
| 129 | 3480355 | 3480558 | + | NC_012912.1 | Dickeya chrysanthemi Ech1591 |
| 130 | 3560844 | 3561047 | + | NZ_CP034036.1 | Brenneria nigrifluens DSM 30175 = ATCC 13028 |
| 131 | 1258942 | 1259145 | - | NZ_CP031560.1 | Dickeya dianthicola |
| 132 | 1278142 | 1278345 | - | NC_014500.1 | Dickeya dadantii 3937 |
| 133 | 1523981 | 1524184 | + | NZ_CP009460.1 | Dickeya fangzhongdai |
| 134 | 2918865 | 2919068 | + | NZ_CP014137.1 | Brenneria goodwinii |
| 135 | 2149021 | 2149224 | - | NZ_CP023009.1 | Lonsdalea britannica |
| 136 | 3382781 | 3382984 | - | NZ_CP015137.1 | Dickeya solani IPO 2222 |
| 137 | 1091851 | 1092027 | - | NZ_CP065534.1 | Lonsdalea populi |
| 138 | 1302393 | 1302596 | - | NZ_CP009125.1 | Pectobacterium atrosepticum |
| 139 | 1330632 | 1330835 | - | NZ_CP038498.1 | Pectobacterium punjabense |
| 140 | 340227 | 340430 | + | NZ_CP047495.1 | Pectobacterium brasiliense |
| 141 | 3542278 | 3542481 | + | NZ_CP051652.1 | Pectobacterium carotovorum |
| 142 | 3716939 | 3717142 | + | NZ_CP065044.1 | Pectobacterium aroidearum |
| 143 | 1388510 | 1388713 | - | NZ_CP034938.1 | Pectobacterium odoriferum |
| 144 | 136127 | 136330 | - | NZ_CP017482.1 | Pectobacterium polaris |
| 145 | 570942 | 571145 | - | NZ_CP015749.1 | Pectobacterium parmentieri |
| 146 | 3206934 | 3207137 | - | NZ_CP015750.1 | Pectobacterium wasabiae CFBP 3304 |
| 147 | 667276 | 667479 | + | NZ_CP023706.1 | Edwardsiella tarda |
| 148 | 3414629 | 3414832 | + | NZ_CP006569.1 | Sodalis praecaptivus |
| 149 | 2971236 | 2971439 | + | NZ_CP006569.1 | Sodalis praecaptivus |
| 150 | 2642114 | 2642317 | + | NZ_CP016043.1 | Edwardsiella hoshinae |
| 151 | 224277 | 224459 | + | NC_016893.1 | Wigglesworthia glossinidia endosymbiont of Glossina morsitans morsitans (Yale colony) |
| 152 | 19846 | 20049 | + | NZ_CP054255.1 | Klebsiella variicola |
| 153 | 95235 | 95438 | + | NZ_CP034939.1 | Pectobacterium odoriferum |
| 154 | 25377 | 25580 | + | NZ_CP026048.1 | Raoultella planticola |
| 155 | 40015 | 40218 | + | NZ_CP065839.1 | Klebsiella quasipneumoniae |
| 156 | 80622 | 80825 | + | NZ_CP026049.1 | Raoultella planticola |
| 157 | 38385 | 38588 | + | NZ_CP036176.1 | Klebsiella huaxiensis |
| 158 | 15326 | 15532 | - | NC_013718.1 | Citrobacter rodentium ICC168 |
| 159 | 53211 | 53420 | + | NC_013717.1 | Citrobacter rodentium ICC168 |
| 160 | 207819 | 208028 | + | NC_004851.1 | Shigella flexneri 2a str. 301 |
| 161 | 71174 | 71383 | + | NC_002128.1 | Escherichia coli O157:H7 str. Sakai |
| 162 | 167838 | 168041 | + | NC_014305.1 | Erwinia billingiae Eb661 |
| 163 | 5936 | 6139 | - | NZ_CP034151.1 | Pantoea agglomerans |
| 164 | 60800 | 60985 | + | NZ_CP045846.1 | Kluyvera intermedia |
| 165 | 62808 | 62993 | - | NZ_CP011601.1 | Phytobacter ursingii |
| 166 | 60511 | 60696 | + | NZ_CP061512.1 | Mixta calida |
| 167 | 1406372 | 1406584 | - | NZ_LS483470.1 | Leminorella richardii |
++ More..
| Neighborhood Conservation Analysis |
* Arrows marked in Genome Diagram shows ORFs; Multiple PFAMs can be mapped to a single ORF.
* 'Small ORF' represents the entry/query analyzed.
* Image generated using 'gggenes'(R-Package).
Neighborhood Representative Chosen(Species): NZ_CP061527.1
| Sr.No. | Domain | Co-occurrence Frequency | No. of species in which domain occurs with smORF | Median distance b/w smORF and domain bearing ORFs | Orientation relative to smORF | PFAM Information |
|---|---|---|---|---|---|---|
| 1 | PF10757.11 | 0.97 | 141 | 30.0 | same-strand | Biofilm formation regulator YbaJ |
| 2 | PF00873.21 | 0.75 | 110 | 946 | same-strand | AcrB/AcrD/AcrF family |
| 3 | PF00529.22 | 0.7 | 102 | 4098 | same-strand | Cation efflux system protein CusB domain 1 |
| 4 | PF16576.7 | 0.7 | 102 | 4098 | same-strand | Barrel-sandwich domain of CusB or HlyD membrane-fusion |
++ More..