Result : P0AAX1
| Protein Information |
| Information Type | Description |
|---|---|
| Protein name | Multidrug efflux pump accessory protein AcrZ (AcrAB-TolC multidrug efflux pump accessory protein AcrZ) (Acridine resistance protein Z) |
| NCBI Accession ID | AE005174.2 |
| Organism | Escherichia coli O157:H7 |
| Left | 880294 |
| Right | 880443 |
| Strand | + |
| Nucleotide Sequence | ATGTTAGAGTTATTAAAAAGTCTGGTATTCGCCGTAATCATGGTACCTGTCGTGATGGCCATCATCCTGGGTCTGATTTACGGTCTTGGTGAAGTATTCAACATCTTTTCTGGTGTTGGTAAAAAAGACCAGCCCGGACAAAATCATTGA |
| Sequence | MLELLKSLVFAVIMVPVVMAIILGLIYGLGEVFNIFSGVGKKDQPGQNH |
| Source of smORF | Swiss-Prot |
| Function | AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. {ECO:0000255|HAMAP-Rule:MF_01484}. |
| Pubmed ID | 11206551 11258796 |
| Domain | CDD:371231 |
| Functional Category | Others |
| Uniprot ID | P0AAX1 |
| ORF Length (Amino Acid) | 49 |
++ More..
| Conservation Analysis |
No. of Species: 142
| Sr.No. | Left Position | Right Position | Strand | NCBI Accession id | Species Name |
|---|---|---|---|---|---|
| 1 | 1438811 | 1438960 | + | NZ_LR134340.1 | Escherichia marmotae |
| 2 | 788248 | 788397 | + | NZ_AP014857.1 | Escherichia albertii |
| 3 | 878647 | 878796 | + | NC_002695.2 | Escherichia coli O157:H7 str. Sakai |
| 4 | 794773 | 794922 | + | NC_000913.3 | Escherichia coli str. K-12 substr. MG1655 |
| 5 | 563241 | 563390 | - | NC_004337.2 | Shigella flexneri 2a str. 301 |
| 6 | 2947173 | 2947322 | - | NZ_CP061527.1 | Shigella dysenteriae |
| 7 | 4052941 | 4053090 | - | NZ_CP045205.1 | Citrobacter telavivensis |
| 8 | 1386403 | 1386552 | - | NZ_CP057657.1 | Escherichia fergusonii |
| 9 | 4316013 | 4316162 | + | NZ_CP033744.1 | Citrobacter freundii |
| 10 | 1859630 | 1859779 | - | NZ_CP038469.1 | Citrobacter tructae |
| 11 | 3199611 | 3199760 | - | NZ_CP045845.1 | Kluyvera intermedia |
| 12 | 3018105 | 3018254 | + | NZ_LT556085.1 | Citrobacter amalonaticus |
| 13 | 834605 | 834754 | + | NC_013716.1 | Citrobacter rodentium ICC168 |
| 14 | 789992 | 790141 | - | NZ_CP044098.1 | Citrobacter portucalensis |
| 15 | 3316425 | 3316574 | + | NZ_CP053416.1 | Salmonella bongori |
| 16 | 845362 | 845511 | + | NC_003197.2 | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 |
| 17 | 3870284 | 3870433 | - | NZ_CP054254.1 | Klebsiella variicola |
| 18 | 1662777 | 1662926 | + | NC_016845.1 | Klebsiella pneumoniae subsp. pneumoniae HS11286 |
| 19 | 1423514 | 1423663 | + | NZ_AP023184.1 | Buttiauxella agrestis |
| 20 | 3614191 | 3614340 | - | NZ_CP065838.1 | Klebsiella quasipneumoniae |
| 21 | 296969 | 297118 | + | NZ_CP023529.1 | Lelliottia amnigena |
| 22 | 296131 | 296280 | - | NZ_CP042941.1 | Atlantibacter hermannii |
| 23 | 570597 | 570746 | + | NZ_CP017279.1 | Enterobacter ludwigii |
| 24 | 1503691 | 1503840 | + | NZ_CP012871.1 | [Enterobacter] lignolyticus |
| 25 | 1484273 | 1484422 | + | NZ_CP015113.1 | Kosakonia radicincitans |
| 26 | 3725250 | 3725399 | - | NZ_CP014007.2 | Kosakonia oryzae |
| 27 | 1504843 | 1504992 | - | NZ_CP045300.1 | Kosakonia arachidis |
| 28 | 3699241 | 3699390 | - | NZ_CP041247.1 | Raoultella electrica |
| 29 | 1583551 | 1583700 | + | NZ_CP043318.1 | Enterobacter chengduensis |
| 30 | 1415456 | 1415605 | + | NZ_CP012266.1 | Cronobacter dublinensis subsp. dublinensis LMG 23823 |
| 31 | 1346645 | 1346794 | + | NC_015968.1 | Enterobacter soli |
| 32 | 2958099 | 2958248 | - | NZ_CP011602.1 | Phytobacter ursingii |
| 33 | 4194862 | 4195011 | - | NZ_CP051548.1 | Phytobacter diazotrophicus |
| 34 | 1371465 | 1371614 | + | NZ_CP012257.1 | Cronobacter universalis NCTC 9529 |
| 35 | 3184194 | 3184343 | - | NZ_CP050150.1 | Hafnia alvei |
| 36 | 2047297 | 2047446 | - | NZ_CP027107.1 | Cronobacter sakazakii |
| 37 | 2673974 | 2674123 | - | NZ_CP012268.1 | Cronobacter muytjensii ATCC 51329 |
| 38 | 2769499 | 2769648 | - | NZ_CP013940.1 | Cronobacter malonaticus LMG 23826 |
| 39 | 3913437 | 3913586 | + | NZ_AP019007.1 | Enterobacter oligotrophicus |
| 40 | 1170214 | 1170363 | - | NZ_CP025034.2 | Enterobacter sp. SGAir0187 |
| 41 | 1340609 | 1340758 | + | NZ_CP017184.1 | Enterobacter roggenkampii |
| 42 | 2125043 | 2125192 | - | NZ_CP045769.1 | Enterobacter cancerogenus |
| 43 | 1370789 | 1370938 | + | NZ_CP012264.1 | Cronobacter condimenti 1330 |
| 44 | 1392517 | 1392666 | + | NZ_AP022508.1 | Enterobacter bugandensis |
| 45 | 1411724 | 1411873 | + | NZ_CP009756.1 | Enterobacter cloacae |
| 46 | 3417388 | 3417537 | - | NZ_CP013990.1 | Leclercia adecarboxylata |
| 47 | 1379910 | 1380059 | + | NZ_CP027986.1 | Enterobacter sichuanensis |
| 48 | 2631531 | 2631680 | + | NZ_CP020388.1 | Pluralibacter gergoviae |
| 49 | 3125103 | 3125255 | - | NZ_CP054058.1 | Scandinavium goeteborgense |
| 50 | 3209808 | 3209969 | - | NZ_CP035129.1 | Kosakonia cowanii |
| 51 | 2985421 | 2985576 | + | NZ_CP040428.1 | Jejubacter calystegiae |
| 52 | 2718059 | 2718208 | - | NC_017910.1 | Shimwellia blattae DSM 4481 = NBRC 105725 |
| 53 | 208400 | 208555 | - | NZ_CP019706.1 | Pantoea alhagi |
| 54 | 1415647 | 1415796 | + | NZ_CP025799.1 | Dickeya zeae |
| 55 | 2872788 | 2872943 | - | NZ_CP038853.1 | Pantoea vagans |
| 56 | 1322839 | 1322988 | - | NZ_CP009460.1 | Dickeya fangzhongdai |
| 57 | 1451717 | 1451866 | + | NZ_CP031560.1 | Dickeya dianthicola |
| 58 | 2814216 | 2814365 | - | NZ_CP042220.2 | Dickeya poaceiphila |
| 59 | 1481040 | 1481189 | + | NC_014500.1 | Dickeya dadantii 3937 |
| 60 | 2921841 | 2921996 | - | NZ_CP045720.1 | Pantoea eucalypti |
| 61 | 3201195 | 3201350 | - | NC_017554.1 | Pantoea ananatis PA13 |
| 62 | 4139049 | 4139204 | + | NZ_CP049115.1 | Pantoea stewartii |
| 63 | 2564412 | 2564576 | - | NC_010694.1 | Erwinia tasmaniensis Et1/99 |
| 64 | 2955024 | 2955173 | - | NZ_LT615367.1 | Dickeya aquatica |
| 65 | 1356142 | 1356285 | + | NZ_LR134494.1 | Serratia quinivorans |
| 66 | 2565664 | 2565798 | + | NZ_LR134494.1 | Serratia quinivorans |
| 67 | 3284077 | 3284226 | - | NC_012912.1 | Dickeya chrysanthemi Ech1591 |
| 68 | 3294898 | 3295053 | - | NZ_CP034036.1 | Brenneria nigrifluens DSM 30175 = ATCC 13028 |
| 69 | 2199346 | 2199495 | - | NC_009792.1 | Citrobacter koseri ATCC BAA-895 |
| 70 | 647927 | 648085 | + | NZ_CP028271.1 | Mixta intestinalis |
| 71 | 1222511 | 1222672 | + | NZ_CP034035.1 | Brenneria rubrifaciens |
| 72 | 1315724 | 1315888 | + | NZ_CP023567.1 | Erwinia pyrifoliae |
| 73 | 1480354 | 1480509 | + | NZ_CP026377.1 | Mixta gaviniae |
| 74 | 3583521 | 3583670 | + | NZ_CP015137.1 | Dickeya solani IPO 2222 |
| 75 | 1266684 | 1266839 | + | NZ_CP065534.1 | Lonsdalea populi |
| 76 | 2340911 | 2341066 | + | NZ_CP023009.1 | Lonsdalea britannica |
| 77 | 1271583 | 1271747 | + | NC_013961.1 | Erwinia amylovora CFBP1430 |
| 78 | 2684356 | 2684502 | - | NZ_CP014137.1 | Brenneria goodwinii |
| 79 | 1384476 | 1384631 | + | NZ_CP061511.1 | Mixta calida |
| 80 | 1344603 | 1344761 | + | NC_012880.1 | Musicola paradisiaca Ech703 |
| 81 | 1187761 | 1187916 | + | NZ_CP034148.1 | Pantoea agglomerans |
| 82 | 2135855 | 2136010 | - | NZ_CP067057.1 | Rahnella aceris |
| 83 | 2323841 | 2323984 | - | NZ_CP034752.1 | Jinshanibacter zhutongyuii |
| 84 | 1556872 | 1557027 | + | NZ_CP009125.1 | Pectobacterium atrosepticum |
| 85 | 1249697 | 1249852 | + | NZ_LN907827.1 | Erwinia gerundensis |
| 86 | 2162642 | 2162785 | - | NZ_CP029185.2 | Limnobaculum parvum |
| 87 | 1507076 | 1507231 | + | NC_014306.1 | Erwinia billingiae Eb661 |
| 88 | 1024945 | 1025088 | + | NZ_CP016043.1 | Edwardsiella hoshinae |
| 89 | 3319683 | 3319838 | - | NZ_CP051652.1 | Pectobacterium carotovorum |
| 90 | 774922 | 775077 | + | NZ_CP015749.1 | Pectobacterium parmentieri |
| 91 | 3651784 | 3651933 | - | NZ_LR134475.1 | Klebsiella aerogenes |
| 92 | 3422068 | 3422223 | + | NZ_CP015750.1 | Pectobacterium wasabiae CFBP 3304 |
| 93 | 3381796 | 3381945 | + | NZ_CP026047.1 | Raoultella planticola |
| 94 | 2718554 | 2718697 | + | NZ_CP023706.1 | Edwardsiella tarda |
| 95 | 3178139 | 3178315 | - | NZ_CP006569.1 | Sodalis praecaptivus |
| 96 | 2296723 | 2296854 | - | NZ_LS483470.1 | Leminorella richardii |
| 97 | 3849517 | 3849666 | - | NZ_CP046672.1 | Raoultella ornithinolytica |
| 98 | 2495505 | 2495639 | + | NC_015567.1 | Serratia plymuthica AS9 |
| 99 | 1392008 | 1392157 | + | NC_015567.1 | Serratia plymuthica AS9 |
| 100 | 1028501 | 1028641 | - | NC_013892.1 | Xenorhabdus bovienii SS-2004 |
| 101 | 2730327 | 2730470 | - | NC_012779.2 | Edwardsiella ictaluri 93-146 |
| 102 | 613519 | 613662 | - | NZ_CP006664.1 | Edwardsiella anguillarum ET080813 |
| 103 | 1769561 | 1769695 | + | NC_005126.1 | Photorhabdus laumondii subsp. laumondii TTO1 |
| 104 | 2571797 | 2571934 | + | NZ_LT906479.1 | Serratia ficaria |
| 105 | 1427800 | 1427949 | + | NZ_LT906479.1 | Serratia ficaria |
| 106 | 4063425 | 4063574 | - | NZ_CP036175.1 | Klebsiella huaxiensis |
| 107 | 3988239 | 3988388 | - | NZ_CP050508.1 | Raoultella terrigena |
| 108 | 2815878 | 2816021 | + | NZ_CP065640.1 | Serratia rubidaea |
| 109 | 2507827 | 2507961 | + | NZ_CP048784.1 | Serratia liquefaciens |
| 110 | 1298429 | 1298578 | + | NZ_CP048784.1 | Serratia liquefaciens |
| 111 | 4229265 | 4229414 | - | NZ_CP060111.1 | Klebsiella michiganensis |
| 112 | 1130672 | 1130815 | + | NZ_CP047349.1 | Proteus terrae subsp. cibarius |
| 113 | 3513939 | 3514073 | + | NZ_CP011104.1 | Photorhabdus thracensis |
| 114 | 1948698 | 1948832 | - | NZ_CP016176.1 | Xenorhabdus hominickii |
| 115 | 1374667 | 1374807 | + | NZ_FO704550.1 | Xenorhabdus doucetiae |
| 116 | 3482247 | 3482399 | - | NZ_CP023525.1 | Cedecea neteri |
| 117 | 648112 | 648255 | + | NC_010554.1 | Proteus mirabilis HI4320 |
| 118 | 3702624 | 3702773 | - | NZ_CP071320.1 | Serratia ureilytica |
| 119 | 2619283 | 2619417 | - | NZ_CP071320.1 | Serratia ureilytica |
| 120 | 661706 | 661855 | + | NZ_CP016948.1 | Serratia surfactantfaciens |
| 121 | 1799619 | 1799753 | + | NZ_CP016948.1 | Serratia surfactantfaciens |
| 122 | 3406867 | 3407001 | - | NC_012962.1 | Photorhabdus asymbiotica |
| 123 | 1356056 | 1356205 | + | NZ_CP038662.1 | Serratia nematodiphila |
| 124 | 2509117 | 2509254 | + | NZ_CP038662.1 | Serratia nematodiphila |
| 125 | 3253714 | 3253866 | - | NZ_LR134201.1 | Cedecea lapagei |
| 126 | 2726564 | 2726707 | + | NZ_CP026364.1 | Proteus hauseri |
| 127 | 3576929 | 3577072 | + | NZ_CP011254.1 | Serratia fonticola |
| 128 | 1166939 | 1167100 | - | NZ_CP014136.1 | Gibbsiella quercinecans |
| 129 | 3289387 | 3289536 | - | NZ_CP048796.1 | Providencia vermicola |
| 130 | 791531 | 791674 | + | NZ_CP060401.1 | Xenorhabdus nematophila |
| 131 | 2258813 | 2258956 | - | NZ_FO704551.1 | Xenorhabdus poinarii G6 |
| 132 | 1576970 | 1577119 | - | NZ_CP016337.1 | Kosakonia sacchari |
| 133 | 1482756 | 1482905 | + | NZ_CP063425.1 | Kosakonia pseudosacchari |
| 134 | 4643693 | 4643836 | - | NZ_CP007044.2 | Chania multitudinisentens RB-25 |
| 135 | 1494644 | 1494784 | + | NZ_CP046293.1 | Yersinia intermedia |
| 136 | 3235242 | 3235382 | - | NZ_CP011118.1 | Yersinia enterocolitica |
| 137 | 3497799 | 3497954 | - | NZ_CP065044.1 | Pectobacterium aroidearum |
| 138 | 1605816 | 1605971 | + | NZ_CP034938.1 | Pectobacterium odoriferum |
| 139 | 108228 | 108383 | - | NZ_CP047495.1 | Pectobacterium brasiliense |
| 140 | 2635590 | 2635730 | - | NZ_CP032487.1 | Yersinia hibernica |
| 141 | 4203240 | 4203380 | + | NZ_CP009781.1 | Yersinia aldovae 670-83 |
| 142 | 2652424 | 2652564 | + | NZ_CP054043.1 | Yersinia mollaretii ATCC 43969 |
| 143 | 356608 | 356763 | + | NZ_CP017482.1 | Pectobacterium polaris |
| 144 | 3223641 | 3223781 | - | NZ_CP043727.1 | Yersinia canariae |
| 145 | 3045535 | 3045681 | - | NZ_CP072455.1 | Xenorhabdus budapestensis |
| 146 | 3149712 | 3149864 | - | NZ_LR134373.1 | Yersinia pseudotuberculosis |
| 147 | 3104836 | 3104988 | + | NZ_CP007230.1 | Yersinia similis |
| 148 | 3474435 | 3474563 | + | NZ_CP011078.1 | Yersinia ruckeri |
| 149 | 1555174 | 1555329 | + | NZ_CP038498.1 | Pectobacterium punjabense |
| 150 | 4288839 | 4288979 | + | NZ_CP009787.1 | Yersinia rohdei |
++ More..
| Neighborhood Conservation Analysis |
* Arrows marked in Genome Diagram shows ORFs; Multiple PFAMs can be mapped to a single ORF.
* 'Small ORF' represents the entry/query analyzed.
* Image generated using 'gggenes'(R-Package).
Neighborhood Representative Chosen(Species): NZ_LR134340.1
| Sr.No. | Domain | Co-occurrence Frequency | No. of species in which domain occurs with smORF | Median distance b/w smORF and domain bearing ORFs | Orientation relative to smORF | PFAM Information |
|---|---|---|---|---|---|---|
| 1 | PF02744.19 | 0.67 | 95 | 3717.5 | opposite-strand | Galactose-1-phosphate uridyl transferase, C-terminal domain |
| 2 | PF01087.24 | 0.67 | 95 | 3717.5 | opposite-strand | Galactose-1-phosphate uridyl transferase, N-terminal domain |
| 3 | PF16363.7 | 0.7 | 99 | 2710.0 | opposite-strand | GDP-mannose 4,6 dehydratase |
| 4 | PF01370.23 | 0.7 | 99 | 2710.0 | opposite-strand | NAD dependent epimerase/dehydratase family |
| 5 | PF08659.12 | 0.69 | 98 | 2703 | opposite-strand | KR domain |
| 6 | PF00005.29 | 0.99 | 141 | 1604 | same-strand | ABC transporter |
| 7 | PF03459.19 | 1.0 | 142 | 1593 | same-strand | TOBE domain |
| 8 | PF00126.29 | 0.96 | 136 | 154.0 | opposite-strand | Bacterial regulatory helix-turn-helix protein, lysR family |
| 9 | PF13531.8 | 0.98 | 139 | 172.5 | same-strand | Bacterial extracellular solute-binding protein |
| 10 | PF01547.27 | 0.98 | 139 | 172.5 | same-strand | Bacterial extracellular solute-binding protein |
| 11 | PF00528.24 | 0.98 | 139 | 943 | same-strand | Binding-protein-dependent transport system inner membrane component |
| 12 | PF08282.14 | 0.87 | 123 | 2712.5 | opposite-strand | haloacid dehalogenase-like hydrolase |
| 13 | PF10282.11 | 0.74 | 105 | 3696.0 | same-strand | Lactonase, 7-bladed beta-propeller |
++ More..