| Protein name |
Lantibiotic lacticin 3147 A2 |
| NCBI Accession ID |
AE001272.1 |
| Organism |
Lactococcus lactis subsp. lactis (Streptococcus lactis) |
| Left |
27963 |
| Right |
28160 |
| Strand |
+ |
| Nucleotide Sequence |
ATGAAAGAAAAAAATATGAAAAAGAATGACACTATTGAATTACAATTGGGAAAATACCTTGAAGATGATATGATTGAATTAGCTGAAGGGGATGAGTCTCATGGAGGAACAACACCAGCAACTCCTGCAATCTCTATTCTCAGTGCATATATTAGTACCAATACTTGTCCAACAACAAAATGTACACGTGCTTGTTAA |
| Sequence |
MKEKNMKKNDTIELQLGKYLEDDMIELAEGDESHGGTTPATPAISILSAYISTNTCPTTKCTRAC |
| Source of smORF |
Swiss-Prot |
| Function |
Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores. When present individually lacticin 3147 A2 exhibits weak activity towards L.lactis strain AM2 and L.lactis strain HP, and no activity towards L.lactis strain IFPL359, but when combined with lacticin 3147 A1 it displays strong activity towards all three strains. {ECO:0000269|Pubmed:10608807, ECO:0000269|Pubmed:10971756}. |
| Pubmed ID |
9767571
10971756
15023056
10608807
|
| Domain |
|
| Functional Category |
Antimicrobial |
| Uniprot ID |
O87237
|
| ORF Length (Amino Acid) |
65 |