ProsmORF-pred
Result : O66524
Protein Information
Information Type Description
Protein name UPF0109 protein aq_124
NCBI Accession ID AE000657.1
Organism Aquifex aeolicus (strain VF5)
Left 78663
Right 78902
Strand +
Nucleotide Sequence ATGAGCGCACTCAAGGACATTGTTGAACTCACAGCAAAAGAATTAGTAGACAACAAGGACAAAGTGAGAGTTACCGAGATTGAAGGAGAAAAGACCGTTGTAATTGAGCTCAGGGTTGACCCTGCTGAGCTCGGTAAGGTTATCGGAAAGCAGGGTAGGATCGCAAGAGCTCTCAGAACCATCCTCACCGCAATCGGTAGAAAGATAGGAAAGAGGGTGGTTCTGGAAATACTTGAGTAA
Sequence MSALKDIVELTAKELVDNKDKVRVTEIEGEKTVVIELRVDPAELGKVIGKQGRIARALRTILTAIGRKIGKRVVLEILE
Source of smORF Swiss-Prot
Function The ORF matches to the profile of cl00098. Profile Description: K homology (KH) RNA-binding domain, type I. Rrp40, also called exosome component 3 (EXOSC3), or ribosomal RNA-processing protein 40, is a non-catalytic component of the RNA exosome complex which has 3'-->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. Mutations of EXOSC3 gene are associated with neurological diseases. Members in this subfamily contain a divergent KH domain that lacks the RNA-binding GXXG motif.
Pubmed ID 9537320
Domain CDD:412160
Functional Category RNA-binding
Uniprot ID O66524
ORF Length (Amino Acid) 79
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Conservation Analysis
Conservation Analysis
No. of Species: 219
Sr.No. Left Position Right Position Strand NCBI Accession id Species Name
1 78663 78902 + NC_000918.1 Aquifex aeolicus VF5
2 1546246 1546485 - NC_017161.1 Hydrogenobacter thermophilus TK-6
3 462991 463230 - NZ_CP007028.1 Thermocrinis ruber
4 355989 356228 - NC_013894.1 Thermocrinis albus DSM 14484
5 1276959 1277198 + NC_014926.1 Thermovibrio ammonificans HB-1
6 1347436 1347675 - NC_012440.1 Persephonella marina EX-H1
7 2090704 2090901 - NC_015672.1 Flexistipes sinusarabici DSM 4947
8 2084640 2084846 + NC_014758.1 Calditerrivibrio nitroreducens DSM 19672
9 124899 125138 + NC_012438.1 Sulfurihydrogenibium azorense Az-Fu1
10 1449539 1449772 - NC_015949.1 Caldicellulosiruptor lactoaceticus 6A
11 1615808 1616038 - NZ_AP022873.1 Dissulfurispira thermophila
12 3741904 3742101 + NC_013173.1 Desulfomicrobium baculatum DSM 4028
13 1121217 1121450 + NZ_CP034791.1 Caldicellulosiruptor changbaiensis
14 2293071 2293304 - NC_009437.1 Caldicellulosiruptor saccharolyticus DSM 8903
15 861253 861486 + NC_014657.1 Caldicellulosiruptor owensensis OL
16 1652759 1652992 - NC_014392.1 Caldicellulosiruptor obsidiansis OB47
17 1786134 1786367 - NC_014652.1 Caldicellulosiruptor hydrothermalis 108
18 1023113 1023346 + NC_014721.1 Caldicellulosiruptor kristjanssonii I77R1B
19 1872142 1872375 - NC_014720.1 Caldicellulosiruptor kronotskyensis 2002
20 1073264 1073497 + NC_012034.1 Caldicellulosiruptor bescii DSM 6725
21 4043247 4043486 - NZ_CP045504.1 Desulfovibrio sulfodismutans DSM 3696
22 387344 387583 - NZ_CP042909.1 Thermosulfurimonas marina
23 2411058 2411291 - NC_013943.1 Denitrovibrio acetiphilus DSM 12809
24 1058165 1058395 + NZ_CP026538.1 Desulfovibrio carbinolicus
25 3904591 3904821 - NC_012796.1 Desulfovibrio magneticus RS-1
26 3012173 3012367 + NZ_CP040098.1 Desulfoglaeba alkanexedens ALDC
27 2810244 2810453 - NZ_CP040098.1 Desulfoglaeba alkanexedens ALDC
28 2617136 2617333 + NZ_CP035108.1 Geovibrio thiophilus
29 3135815 3136054 - NZ_CP045508.1 Desulfolutivibrio sulfoxidireducens
30 212250 212480 + NC_012881.1 Maridesulfovibrio salexigens DSM 2638
31 2159265 2159504 - NC_016620.1 Halobacteriovorax marinus SJ
32 3702409 3702603 + NC_008554.1 Syntrophobacter fumaroxidans MPOB
33 3747161 3747355 + NC_008554.1 Syntrophobacter fumaroxidans MPOB
34 3913831 3914043 + NC_008554.1 Syntrophobacter fumaroxidans MPOB
35 565653 565886 - NC_016629.1 Desulfocurvibacter africanus subsp. africanus str. Walvis Bay
36 842515 842709 + NC_014844.1 Pseudodesulfovibrio aespoeensis Aspo-2
37 410300 410533 - NZ_AP013035.1 Thermosulfidibacter takaii ABI70S6
38 1305723 1305962 + NC_015681.1 Thermodesulfatator indicus DSM 15286
39 5374758 5374997 + NZ_CP063849.1 Paludibaculum fermentans
40 705841 706080 + NC_015682.1 Thermodesulfobacterium geofontis OPF15
41 1214405 1214638 + NC_017583.1 Spirochaeta thermophila DSM 6578
42 323221 323451 + NZ_AP017470.1 Thermotomaculum hydrothermale
43 1169847 1170092 + NC_014831.1 Thermaerobacter marianensis DSM 12885
44 815508 815747 + NZ_AP014945.1 Caldimicrobium thiodismutans
45 2619695 2619889 + NZ_LT907975.1 Pseudodesulfovibrio profundus
46 1794629 1794823 + NZ_CP046400.1 Pseudodesulfovibrio cashew
47 2319094 2319288 - NZ_CP014229.1 Desulfovibrio fairfieldensis
48 705170 705403 - NC_020127.1 Lawsonia intracellularis N343
49 1884333 1884572 - NZ_CP048877.1 Thermosulfuriphilus ammonigenes
50 873196 873426 + NC_015388.1 Desulfobacca acetoxidans DSM 11109
51 2208088 2208318 - NZ_CP039543.1 Desulfovibrio marinus
52 3505655 3505852 - NC_014365.1 Desulfarculus baarsii DSM 2075
53 81499 81738 - NZ_CP008796.1 Thermodesulfobacterium commune DSM 2178
54 2032206 2032439 + NC_014364.1 Sediminispirochaeta smaragdinae DSM 11293
55 931368 931562 - NC_017310.1 Desulfovibrio vulgaris RCH1
56 2189515 2189745 - NZ_CP061799.1 Desulfonema limicola
57 1290217 1290450 + NZ_CP036150.1 Oceanispirochaeta crateris
58 6750974 6751204 + NZ_AP021875.1 Desulfosarcina widdelii
59 6559151 6559381 - NZ_AP021875.1 Desulfosarcina widdelii
60 2377538 2377732 - NC_007759.1 Syntrophus aciditrophicus SB
61 2196388 2196618 - NC_007759.1 Syntrophus aciditrophicus SB
62 3932517 3932747 + NC_018645.1 Desulfobacula toluolica Tol2
63 3537001 3537231 - NC_018645.1 Desulfobacula toluolica Tol2
64 2794918 2795139 - NC_009943.1 Desulfococcus oleovorans Hxd3
65 436424 436654 + NC_018025.1 Desulfomonile tiedjei DSM 6799
66 6455347 6455541 + NZ_AP021874.1 Desulfosarcina alkanivorans
67 6131484 6131714 - NZ_AP021874.1 Desulfosarcina alkanivorans
68 490486 490683 - NZ_AP021874.1 Desulfosarcina alkanivorans
69 2825922 2826116 - NZ_AP021876.1 Desulfosarcina ovata subsp. sediminis
70 3129796 3130035 + NZ_AP021876.1 Desulfosarcina ovata subsp. sediminis
71 4286370 4286564 - NZ_AP021876.1 Desulfosarcina ovata subsp. sediminis
72 4219935 4220129 - NZ_AP021876.1 Desulfosarcina ovata subsp. sediminis
73 2216828 2217058 + NZ_AP021876.1 Desulfosarcina ovata subsp. sediminis
74 1278815 1279054 + NZ_CP027286.1 Clostridium chauvoei
75 5757006 5757236 - NC_011768.1 Desulfatibacillum aliphaticivorans
76 1391632 1391865 + NC_017098.1 Spirochaeta africana DSM 8902
77 1181035 1181265 + NZ_CP035130.1 Gudongella oleilytica
78 2301159 2301389 + NZ_CP059066.1 Koleobacter methoxysyntrophicus
79 2287595 2287792 - NZ_AP017378.1 Desulfovibrio ferrophilus
80 535506 535739 - NC_015732.1 Treponema caldarium DSM 7334
81 2322478 2322675 - NC_013223.1 Desulfohalobium retbaense DSM 5692
82 1442725 1442952 + NC_011837.1 Clostridium kluyveri NBRC 12016
83 1193522 1193749 + NZ_CP032416.1 Clostridium fermenticellae
84 3519208 3519438 - NC_012108.1 Desulfobacterium autotrophicum HRM2
85 1852231 1852425 + NC_023035.1 Salinispira pacifica
86 1396684 1396911 + NZ_CP043998.1 Clostridium diolis
87 2574031 2574261 + NZ_CP061800.1 Desulfonema magnum
88 943982 944212 + NZ_CP018099.1 Caldithrix abyssi DSM 13497
89 1186150 1186377 + NZ_CP020953.1 Clostridium drakei
90 3081830 3082057 - NZ_CP009933.1 Clostridium scatologenes
91 257157 257387 - NC_013939.1 Deferribacter desulfuricans SSM1
92 3625733 3625960 + NZ_CP012395.1 Clostridium autoethanogenum DSM 10061
93 1389677 1389904 + NC_014328.1 Clostridium ljungdahlii DSM 13528
94 1251506 1251733 + NC_015519.1 Tepidanaerobacter acetatoxydans Re1
95 147423 147650 + NZ_CP011803.1 Clostridium carboxidivorans P7
96 596683 596916 + NC_015436.1 Sphaerochaeta coccoides DSM 17374
97 2873073 2873303 + NC_014836.1 Desulfurispirillum indicum S5
98 187728 187967 - NZ_CP023671.1 Clostridium septicum
99 1056680 1056910 + NC_018870.1 Thermacetogenium phaeum DSM 12270
100 1844551 1844778 + NZ_CP040924.1 Clostridium thermarum
101 543800 543994 - NC_016633.1 Sphaerochaeta pleomorpha str. Grapes
102 1104765 1104998 + NC_015500.1 Treponema brennaborense DSM 12168
103 793560 793793 - NZ_CP035807.1 Thiospirochaeta perfilievii
104 2250539 2250766 - NC_009253.1 Desulfotomaculum reducens MI-1
105 2100855 2101082 - NZ_CP019698.1 Desulfotomaculum ferrireducens
106 2028898 2029137 - NC_005363.1 Bdellovibrio bacteriovorus HD100
107 1047283 1047510 + NC_014377.1 Thermosediminibacter oceani DSM 16646
108 1905379 1905615 + NC_015687.1 Clostridium acetobutylicum DSM 1731
109 1200557 1200784 + NZ_CP017253.2 Clostridium taeniosporum
110 1420236 1420478 + NC_014330.1 Brachyspira pilosicoli 95/1000
111 2993507 2993749 - NC_017243.1 Brachyspira intermedia PWS/A
112 1486976 1487203 - NZ_LR590481.1 Hathewaya histolytica
113 1879049 1879279 - NZ_CP025197.1 Acetivibrio saccincola
114 1759883 1760113 - NC_014378.1 Acetohalobium arabaticum DSM 5501
115 1767225 1767422 - NZ_CP054142.1 Treponema parvum
116 1055514 1055741 + NZ_LT906477.1 Clostridium cochlearium
117 2140467 2140697 - NZ_CP014223.1 Anaerotignum propionicum DSM 1682
118 1425843 1426037 + NZ_CP014230.1 Desulfomicrobium orale DSM 12838
119 946577 946795 + NC_014220.1 Syntrophothermus lipocalidus DSM 12680
120 2526999 2527226 - NZ_CP028842.1 Clostridium botulinum
121 2789485 2789712 - NZ_CP011663.1 Clostridium sporogenes
122 1010854 1011087 - NC_015578.1 Treponema primitia ZAS-2
123 1413377 1413583 + NC_015152.1 Sphaerochaeta globosa str. Buddy
124 1951490 1951705 + NZ_CP045875.1 Heliorestis convoluta
125 1574135 1574362 + NC_022571.1 Clostridium saccharobutylicum DSM 13864
126 1574236 1574466 + NC_009922.1 Alkaliphilus oremlandii OhILAs
127 1219348 1219566 + NC_013216.1 Desulfofarcimen acetoxidans DSM 771
128 1442360 1442590 + NC_010718.1 Natranaerobius thermophilus JW/NM-WN-LF
129 911979 912209 + NZ_CP017237.1 Moorella thermoacetica
130 4812860 4813090 - NZ_CP026520.1 Paenibacillus chitinolyticus
131 1166504 1166743 - NZ_CP016786.1 Clostridium isatidis
132 1058094 1058291 - NC_015385.1 Treponema succinifaciens DSM 2489
133 1822407 1822634 + NC_015589.1 Desulfotomaculum ruminis DSM 2154
134 2431802 2432032 + NZ_CP039126.1 Blautia producta
135 3683085 3683324 - NZ_CP071376.1 Clostridium gasigenes
136 3401680 3401907 + NZ_CP063356.1 Anaerobacillus isosaccharinicus
137 2378771 2378998 - NZ_CP020559.1 Clostridium formicaceticum
138 58802 59029 + NZ_LR130778.1 Petrocella atlantisensis
139 3001069 3001299 + NC_016803.1 Pseudodesulfovibrio mercurii
140 1700180 1700410 - NC_018664.1 Gottschalkia acidurici 9a
141 2016243 2016485 + NZ_CP019914.1 Brachyspira hampsonii
142 1286337 1286579 + NC_014150.1 Brachyspira murdochii DSM 12563
143 3730541 3730735 - NC_015577.1 Treponema azotonutricium ZAS-9
144 2129425 2129652 - NZ_CP009687.1 Clostridium aceticum
145 1117464 1117694 - NZ_CP068564.1 Keratinibaculum paraultunense
146 2184826 2185020 + NC_010337.2 Heliomicrobium modesticaldum Ice1
147 2009451 2009681 + NC_016627.1 Acetivibrio clariflavus DSM 19732
148 2128590 2128820 - NZ_LR699011.1 Roseburia hominis
149 790995 791222 + NC_011899.1 Halothermothrix orenii H 168
150 1061952 1062170 - NC_012778.1 [Eubacterium] eligens ATCC 27750
151 2496316 2496546 - NC_016894.1 Acetobacterium woodii DSM 1030
152 1432508 1432741 - NZ_CP009228.1 Treponema putidum
153 901589 901822 + NC_002967.9 Treponema denticola ATCC 35405
154 1302698 1302928 + NC_020134.1 Thermoclostridium stercorarium subsp. stercorarium DSM 8532
155 3434486 3434704 + NZ_CP021434.1 Tumebacillus avium
156 2673142 2673372 - NC_014624.2 Eubacterium callanderi
157 4300000 4300230 + NZ_CP029487.1 Eubacterium maltosivorans
158 3103262 3103492 + NZ_CP019962.1 Eubacterium limosum
159 3290318 3290548 - NZ_LR027880.1 Roseburia intestinalis L1-82
160 1945705 1945935 + NZ_CP021850.1 Pseudoclostridium thermosuccinogenes
161 6385927 6386157 - NC_017672.3 Paenibacillus mucilaginosus K02
162 1715469 1715705 - NC_008346.1 Syntrophomonas wolfei subsp. wolfei str. Goettingen G311
163 173706 173954 - NZ_CP024333.1 Borrelia miyamotoi
164 1472409 1472627 - NC_014410.1 Thermoanaerobacterium thermosaccharolyticum DSM 571
165 2761250 2761480 - NC_009633.1 Alkaliphilus metalliredigens QYMF
166 301781 302011 - NZ_CP017269.1 Geosporobacter ferrireducens
167 2254782 2254979 + NZ_CP031518.1 Treponema ruminis
168 1241009 1241239 + NZ_CP013652.1 Paenibacillus naphthalenovorans
169 1987748 1987984 - NZ_CP012502.1 Bacillus beveridgei
170 1208494 1208724 + NZ_LN879430.1 Herbinix luporum
171 1405817 1406044 - NC_015555.1 Thermoanaerobacterium xylanolyticum LX-11
172 1482717 1482944 - NZ_CP047602.1 Thermoanaerobacterium aotearoense
173 2640928 2641122 - NC_022097.1 Treponema pedis str. T A4
174 1688385 1688612 - NZ_CP014204.2 Clostridium baratii
175 2931500 2931718 - NZ_CP022657.1 Tumebacillus algifaecis
176 1228584 1228814 + NZ_CP007452.1 Peptoclostridium acidaminophilum DSM 3953
177 1278244 1278483 + NC_020813.1 Bdellovibrio exovorus JSS
178 1416594 1416821 - NC_013385.1 Ammonifex degensii KC4
179 1713376 1713606 + NZ_CP016502.1 Acetivibrio thermocellus DSM 2360
180 9200557 9200751 + NZ_CP012333.1 Labilithrix luteola
181 1403722 1403949 - NC_008593.1 Clostridium novyi NT
182 1807028 1807255 - NZ_CP014170.1 Clostridium tyrobutyricum
183 1425547 1425774 + NZ_CP019699.1 Novibacillus thermophilus
184 2599937 2600164 + NZ_CP026363.1 Brevibacillus agri
185 3087909 3088139 - NZ_CP054140.1 Desulfobulbus oligotrophicus
186 2388553 2388780 + NZ_LR134338.1 Brevibacillus brevis
187 1280051 1280278 - NC_007503.1 Carboxydothermus hydrogenoformans Z-2901
188 1307487 1307714 - NC_014964.1 Thermoanaerobacter brockii subsp. finnii Ako-1
189 1419012 1419239 - NC_015958.1 Thermoanaerobacter wiegelii Rt8.B1
190 3258498 3258725 - NZ_CP022464.2 Enterocloster bolteae
191 2343074 2343304 - NC_015172.1 Syntrophobotulus glycolicus DSM 8271
192 307563 307796 - NC_018178.1 Melioribacter roseus P3M-2
193 2268262 2268489 - NC_014376.1 [Clostridium] saccharolyticum WM1
194 2786125 2786352 - NC_021184.1 Desulfoscipio gibsoniae DSM 7213
195 2165262 2165489 - NZ_CP048103.1 Kroppenstedtia eburnea
196 1303307 1303534 - NC_014209.1 Thermoanaerobacter mathranii subsp. mathranii str. A3
197 1281509 1281736 - NC_013921.1 Thermoanaerobacter italicus Ab9
198 1377157 1377375 + NZ_CP048649.1 Aminipila butyrica
199 3238907 3239137 - NC_018017.1 Desulfitobacterium dehalogenans ATCC 51507
200 1433348 1433575 - NC_003869.1 Caldanaerobacter subterraneus subsp. tengcongensis MB4
201 3795994 3796224 - NC_018068.1 Desulfosporosinus acidiphilus SJ4
202 3737265 3737459 - NZ_CP021780.1 Paenibacillus donghaensis
203 4880561 4880791 - NC_016584.1 Desulfosporosinus orientis DSM 765
204 3885379 3885609 - NC_018515.1 Desulfosporosinus meridiei DSM 13257
205 2746780 2747010 - NC_014972.1 Desulfobulbus propionicus DSM 2032
206 1126951 1127181 - NC_007519.1 Desulfovibrio alaskensis G20
207 4652988 4653218 + NZ_CP041217.1 Saccharibacillus brassicae
208 2165621 2165851 + NZ_CP046932.1 Brachyspira hyodysenteriae
209 1385180 1385404 - NC_014216.1 Desulfurivibrio alkaliphilus AHT 2
210 613765 613995 + NC_019978.1 Halobacteroides halobius DSM 5150
211 2567324 2567521 - NZ_CP018866.1 Sutcliffiella cohnii
212 1439602 1439832 + NC_015318.1 Hippea maritima DSM 10411
213 552190 552417 + NZ_CP016379.1 Anoxybacter fermentans
214 2015455 2015685 - NZ_CP030280.1 Blautia argi
215 868953 869186 + NC_017464.1 Ignavibacterium album JCM 16511
216 253631 253861 - NZ_LT990039.1 Massilistercora timonensis
217 270516 270746 + NZ_CP070062.1 Coprococcus comes
218 1818233 1818481 + NZ_CP019066.1 Tsukamurella tyrosinosolvens
219 4803763 4803975 + NZ_CP017316.1 Streptomyces rubrolavendulae
220 4990019 4990231 + NZ_CP023696.1 Streptomyces fradiae ATCC 10745 = DSM 40063
221 1695487 1695735 + NC_014158.1 Tsukamurella paurometabola DSM 20162
222 5894603 5894815 + NZ_CP013738.1 Streptomyces globisporus C-1027
223 6083437 6083649 + NC_021177.1 Streptomyces fulvissimus DSM 40593
224 2236451 2236663 - NC_010572.1 Streptomyces griseus subsp. griseus NBRC 13350
225 6019482 6019694 + NZ_CP070242.1 Streptomyces californicus
226 6076547 6076759 + NZ_CP020570.1 Streptomyces violaceoruber
227 755274 755468 + NC_011244.1 Borrelia recurrentis A1
228 739866 740114 + NZ_CP028861.1 Borreliella garinii
229 734513 734761 + NC_015921.1 Borreliella bissettii DN127
230 734685 734933 + NZ_CP044535.1 Borrelia maritima
231 737791 738039 + NZ_CP015796.1 Borreliella mayonii
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Neighborhood Conservation Analysis
* Arrows marked in Genome Diagram shows ORFs; Multiple PFAMs can be mapped to a single ORF.
* 'Small ORF' represents the entry/query analyzed.
* Image generated using 'gggenes'(R-Package).
Neighborhood Conservation Analysis
Neighborhood Representative Chosen(Species): NC_015672.1
Sr.No. Domain Co-occurrence Frequency No. of species in which domain occurs with smORF Median distance b/w smORF and domain bearing ORFs Orientation relative to smORF PFAM Information
1 PF00886.21 1.0 219 30.0 same-strand Ribosomal protein S16
2 PF00448.24 0.91 199 383.5 same-strand SRP54-type protein, GTPase domain
3 PF02978.21 0.91 199 346.0 same-strand Signal peptide binding domain
4 PF02881.21 0.91 199 383.5 same-strand SRP54-type protein, helical bundle domain
5 PF01245.22 0.84 183 1546.0 same-strand Ribosomal protein L19
6 PF01746.23 0.91 199 588.5 same-strand tRNA (Guanine-1)-methyltransferase
7 PF01782.20 0.95 208 51 same-strand RimM N-terminal domain
8 PF05239.18 0.8 176 63 same-strand PRC-barrel domain
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