Result : O53353
| Protein Information |
| Information Type | Description |
|---|---|
| Protein name | Transcriptional regulator WhiB2 (Probable chaperone WhiB2) |
| NCBI Accession ID | AL123456.3 |
| Organism | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
| Left | 3639872 |
| Right | 3640141 |
| Strand | - |
| Nucleotide Sequence | TTGGTTCCCGAGGCGCCGGCGCCATTCGAGGAACCTCTGCCGCCGGAAGCCACCGACCAATGGCAGGACCGTGCGCTATGTGCGCAAACGGATCCCGAAGCGTTCTTCCCGGAGAAGGGCGGCTCCACGCGTGAGGCCAAGAAGATTTGCATGGGCTGCGAGGTGCGGCACGAGTGTCTGGAGTACGCCCTGGCTCATGACGAGCGGTTCGGCATCTGGGGTGGTCTTTCCGAACGCGAGCGCCGCCGCCTCAAACGCGGGATCATCTGA |
| Sequence | MVPEAPAPFEEPLPPEATDQWQDRALCAQTDPEAFFPEKGGSTREAKKICMGCEVRHECLEYALAHDERFGIWGGLSERERRRLKRGII |
| Source of smORF | Swiss-Prot |
| Function | Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA (By similarity). {ECO:0000250}.; The apo-form functions as a chaperone, preventing aggregation or helping in correct refolding of a number of substrates; this activity does not require ATP or the ability to bind a Fe-S cluster. Chaperone activity is insensitive to the redox state of its cysteine residues. The apo-form has no protein disulfide reductase activity. The apo-form binds to its own promoter. {ECO:0000269|Pubmed:19016840, ECO:0000269|Pubmed:22686939}. |
| Pubmed ID | 9634230 19016840 20545868 22686939 |
| Domain | CDD:396843 |
| Functional Category | DNA-binding_and_Metal-binding |
| Uniprot ID | O53353 |
| ORF Length (Amino Acid) | 89 |
++ More..
| Conservation Analysis |
No. of Species: 178
| Sr.No. | Left Position | Right Position | Strand | NCBI Accession id | Species Name |
|---|---|---|---|---|---|
| 1 | 3639872 | 3640141 | - | NC_000962.3 | Mycobacterium tuberculosis H37Rv |
| 2 | 3697157 | 3697426 | - | NC_015848.1 | Mycobacterium canettii CIPT 140010059 |
| 3 | 1243535 | 1243807 | + | NZ_AP018164.1 | Mycobacterium shigaense |
| 4 | 932983 | 933255 | - | NZ_AP022615.1 | Mycobacterium heidelbergense |
| 5 | 3186803 | 3187075 | - | NZ_AP022590.1 | Mycobacterium mantenii |
| 6 | 4146229 | 4146501 | - | NZ_CP009360.4 | Mycobacterium avium subsp. hominissuis |
| 7 | 454916 | 455185 | + | NZ_AP022581.1 | Mycobacterium lacus |
| 8 | 882066 | 882335 | + | NZ_CP029543.1 | Mycobacterium leprae |
| 9 | 1348664 | 1348945 | + | NZ_LR130759.1 | Mycobacterium basiliense |
| 10 | 4297279 | 4297551 | - | NC_016946.1 | Mycobacterium intracellulare ATCC 13950 |
| 11 | 4431606 | 4431878 | - | NC_016948.1 | Mycobacterium paraintracellulare |
| 12 | 4185793 | 4186065 | - | NZ_CP023147.1 | Mycobacterium marseillense |
| 13 | 2714330 | 2714599 | - | NZ_AP022575.1 | Mycobacterium shinjukuense |
| 14 | 5281547 | 5281819 | + | NZ_AP022619.1 | Mycobacterium paraseoulense |
| 15 | 3079145 | 3079378 | - | NZ_AP022614.1 | Mycobacterium parmense |
| 16 | 5469618 | 5469890 | + | NZ_AP022582.1 | Mycobacterium seoulense |
| 17 | 1541140 | 1541391 | + | NZ_CP025546.1 | Mycobacterium paragordonae |
| 18 | 1014895 | 1015164 | + | NZ_CP011883.2 | Mycobacterium haemophilum DSM 44634 |
| 19 | 2326786 | 2327064 | - | NZ_AP022576.1 | Mycobacterium florentinum |
| 20 | 5129790 | 5130059 | + | NZ_AP022573.1 | Mycobacterium saskatchewanense |
| 21 | 5827539 | 5827820 | - | NZ_AP022572.1 | Mycobacterium shottsii |
| 22 | 1590779 | 1591060 | + | NZ_AP018410.1 | Mycobacterium pseudoshottsii JCM 15466 |
| 23 | 2982039 | 2982320 | + | NZ_CP058277.1 | Mycobacterium marinum |
| 24 | 2983362 | 2983625 | + | NZ_AP022583.1 | Mycobacterium noviomagense |
| 25 | 1402099 | 1402371 | - | NZ_AP022568.1 | Mycobacterium simiae |
| 26 | 3753836 | 3754060 | - | NZ_AP024310.1 | Mycobacterium heckeshornense |
| 27 | 915642 | 915932 | + | NZ_AP022613.1 | Mycobacterium conspicuum |
| 28 | 307773 | 308024 | - | NZ_AP022606.1 | Mycobacterium branderi |
| 29 | 4766564 | 4766830 | + | NZ_AP022569.1 | Mycobacterium cookii |
| 30 | 1271021 | 1271275 | + | NZ_LT906483.1 | Mycolicibacterium thermoresistibile |
| 31 | 378043 | 378306 | - | NZ_AP022595.1 | Mycolicibacterium sarraceniae |
| 32 | 5931700 | 5931966 | - | NZ_AP022598.1 | Mycolicibacterium parafortuitum |
| 33 | 1210820 | 1211074 | + | NC_014158.1 | Tsukamurella paurometabola DSM 20162 |
| 34 | 1333615 | 1333869 | + | NZ_CP019066.1 | Tsukamurella tyrosinosolvens |
| 35 | 2961386 | 2961664 | - | NZ_AP022586.1 | Mycolicibacterium litorale |
| 36 | 3426399 | 3426677 | - | NZ_AP022617.1 | Mycolicibacterium monacense |
| 37 | 2018158 | 2018421 | - | NZ_AP022565.1 | Mycolicibacterium alvei |
| 38 | 3942405 | 3942656 | - | NZ_CP022208.1 | Rhodococcus pyridinivorans |
| 39 | 3600223 | 3600474 | - | NZ_LT906450.1 | Rhodococcus rhodochrous |
| 40 | 1346244 | 1346507 | + | NZ_AP022561.1 | Mycolicibacterium aichiense |
| 41 | 2273437 | 2273670 | + | NZ_AP023172.1 | Rhodococcus qingshengii |
| 42 | 2762100 | 2762354 | - | NZ_CP048813.1 | Rhodococcus triatomae |
| 43 | 3860734 | 3861000 | + | NZ_AP022596.1 | Mycolicibacterium helvum |
| 44 | 3763816 | 3764049 | - | NZ_CP027793.1 | Rhodococcus hoagii |
| 45 | 545461 | 545730 | + | NZ_LR026975.1 | Mycolicibacterium hassiacum DSM 44199 |
| 46 | 5584770 | 5585024 | + | NZ_AP022616.1 | Mycolicibacterium phocaicum |
| 47 | 2593774 | 2594076 | - | NZ_AP022609.1 | Mycolicibacter hiberniae |
| 48 | 1978862 | 1979098 | + | NZ_LN831039.1 | Mycolicibacterium smegmatis |
| 49 | 2943867 | 2944133 | - | NZ_AP022563.1 | Mycolicibacterium duvalii |
| 50 | 47505 | 47738 | - | NZ_CP015235.1 | Rhodococcus fascians D188 |
| 51 | 4065587 | 4065844 | - | NZ_CP011530.1 | Mycobacteroides immunogenum |
| 52 | 3386140 | 3386403 | - | NZ_CP029146.1 | Rhodococcus ruber |
| 53 | 6373371 | 6373625 | - | NZ_CP012150.1 | Mycobacterium goodii |
| 54 | 3663962 | 3664216 | - | NZ_CP014955.1 | Mycobacteroides abscessus |
| 55 | 1480892 | 1481161 | + | NZ_LR134356.1 | Mycolicibacterium aurum |
| 56 | 4866673 | 4866930 | + | NZ_AP022567.1 | Mycolicibacterium mageritense |
| 57 | 934373 | 934651 | + | NZ_CP041695.1 | Nocardia otitidiscaviarum |
| 58 | 4408030 | 4408287 | - | NZ_CP041695.1 | Nocardia otitidiscaviarum |
| 59 | 5368593 | 5368850 | - | NZ_CP020809.1 | Mycobacterium dioxanotrophicus |
| 60 | 740594 | 740899 | - | NZ_AP022589.1 | Mycolicibacter minnesotensis |
| 61 | 4218734 | 4218961 | + | NZ_LS483468.1 | Rhodococcus coprophilus |
| 62 | 4197586 | 4197840 | - | NZ_CP062008.1 | Mycolicibacterium mucogenicum DSM 44124 |
| 63 | 3362619 | 3362873 | - | NZ_CP010271.1 | Mycobacteroides saopaulense |
| 64 | 2444084 | 2444338 | + | NZ_CP027114.1 | Gordonia alkanivorans |
| 65 | 5826201 | 5826458 | - | NZ_AP022579.1 | Mycolicibacterium boenickei |
| 66 | 1289974 | 1290228 | + | NZ_CP011853.1 | Gordonia phthalatica |
| 67 | 3651937 | 3652191 | - | NZ_AP022612.1 | Mycolicibacterium confluentis |
| 68 | 1521327 | 1521590 | + | NZ_CP011491.1 | Mycolicibacterium vaccae 95051 |
| 69 | 5530965 | 5531222 | + | NZ_AP022620.1 | Mycolicibacterium anyangense |
| 70 | 3701254 | 3701508 | - | NZ_AP018165.1 | [Mycobacterium] stephanolepidis |
| 71 | 3691682 | 3691936 | - | NZ_CP007220.1 | Mycobacteroides chelonae CCUG 47445 |
| 72 | 1842409 | 1842678 | + | NC_008726.1 | Mycolicibacterium vanbaalenii PYR-1 |
| 73 | 793436 | 793666 | - | NZ_AP022599.1 | Mycolicibacterium pulveris |
| 74 | 2598905 | 2599159 | + | NZ_CP059694.1 | Gordonia rubripertincta |
| 75 | 3655619 | 3655873 | - | NZ_LR134355.1 | Mycolicibacterium chitae |
| 76 | 3179609 | 3179863 | - | NZ_CP027433.1 | Gordonia iterans |
| 77 | 3532041 | 3532295 | - | NC_013441.1 | Gordonia bronchialis DSM 43247 |
| 78 | 2559803 | 2560084 | - | NZ_AP022608.1 | Mycolicibacterium gadium |
| 79 | 5205933 | 5206205 | - | NZ_AP022560.1 | Mycolicibacterium moriokaense |
| 80 | 5829544 | 5829825 | + | NZ_AP022601.1 | Mycobacterium gallinarum |
| 81 | 3429060 | 3429314 | - | NZ_CP024633.1 | Mycobacteroides salmoniphilum |
| 82 | 5657890 | 5658144 | + | NZ_CP060404.1 | Streptomyces buecherae |
| 83 | 5731161 | 5731403 | + | NZ_CP023688.1 | Streptomyces rimosus |
| 84 | 5187205 | 5187468 | + | NZ_CP032698.1 | Streptomyces hundungensis |
| 85 | 2866815 | 2867078 | - | NZ_CP020700.1 | Streptomyces tsukubensis |
| 86 | 2750037 | 2750300 | - | NZ_CP042266.1 | Streptomyces qinzhouensis |
| 87 | 5008137 | 5008421 | - | NZ_CP015163.1 | Amycolatopsis albispora |
| 88 | 1562099 | 1562356 | + | NZ_AP022610.1 | Mycolicibacterium madagascariense |
| 89 | 4353200 | 4353463 | + | NZ_CP065253.1 | Streptomyces clavuligerus |
| 90 | 766943 | 767191 | - | NZ_CP065253.1 | Streptomyces clavuligerus |
| 91 | 7514246 | 7514509 | + | NZ_CP031142.1 | Saccharopolyspora pogona |
| 92 | 2605681 | 2605944 | - | NZ_CP031194.1 | Streptomyces paludis |
| 93 | 3816571 | 3816813 | - | NZ_CP020569.1 | Streptomyces gilvosporeus |
| 94 | 6106504 | 6106767 | - | NZ_CP030862.1 | Streptomyces globosus |
| 95 | 2271410 | 2271673 | - | NC_020990.1 | Streptomyces albidoflavus |
| 96 | 2700387 | 2700650 | - | NZ_CP031742.1 | Streptomyces koyangensis |
| 97 | 4607303 | 4607566 | + | NZ_CP023701.1 | Streptomyces subrutilus |
| 98 | 4534675 | 4534938 | + | NZ_CP023692.1 | Streptomyces vinaceus |
| 99 | 3068462 | 3068704 | - | NZ_CP072931.1 | Streptomyces auratus AGR0001 |
| 100 | 3457808 | 3458050 | - | NZ_CP019457.1 | Streptomyces lydicus |
| 101 | 3535614 | 3535856 | - | NZ_CP023691.1 | Streptomyces platensis |
| 102 | 3867478 | 3867741 | - | NZ_CP071139.1 | Streptomyces nojiriensis |
| 103 | 5756075 | 5756338 | + | NZ_AP023440.1 | Streptomyces glomeroaurantiacus |
| 104 | 4246224 | 4246466 | - | NZ_CP070326.1 | Streptomyces noursei |
| 105 | 2939092 | 2939355 | - | NZ_CP072827.1 | Streptomyces mobaraensis NBRC 13819 = DSM 40847 |
| 106 | 4408712 | 4408954 | + | NZ_CP023202.1 | Streptomyces xinghaiensis S187 |
| 107 | 4472183 | 4472437 | + | NZ_CP034279.1 | Streptomyces ficellus |
| 108 | 1062467 | 1062718 | - | NZ_CP034279.1 | Streptomyces ficellus |
| 109 | 2991545 | 2991808 | - | NC_021177.1 | Streptomyces fulvissimus DSM 40593 |
| 110 | 7283356 | 7283595 | + | NC_021177.1 | Streptomyces fulvissimus DSM 40593 |
| 111 | 1097672 | 1097908 | + | NZ_CP015961.1 | Dietzia timorensis |
| 112 | 7286268 | 7286516 | - | NZ_CP023445.1 | Actinosynnema pretiosum |
| 113 | 7424259 | 7424507 | - | NC_013093.1 | Actinosynnema mirum DSM 43827 |
| 114 | 2908347 | 2908610 | - | NZ_CP040752.1 | Streptomyces rectiverticillatus |
| 115 | 4263238 | 4263501 | - | NZ_CP031455.1 | Streptomyces olivoreticuli subsp. olivoreticuli |
| 116 | 2599303 | 2599566 | - | NZ_CP054938.1 | Streptomyces harbinensis |
| 117 | 2667723 | 2667986 | - | NZ_CP024957.1 | Streptomyces cavourensis |
| 118 | 6820179 | 6820418 | + | NZ_CP024957.1 | Streptomyces cavourensis |
| 119 | 5596686 | 5596940 | - | NC_016582.1 | Streptomyces bingchenggensis BCW-1 |
| 120 | 2790194 | 2790457 | - | NZ_CP020563.1 | Kitasatospora albolonga |
| 121 | 4904206 | 4904460 | - | NZ_CP065050.1 | Streptomyces solisilvae |
| 122 | 1988373 | 1988636 | - | NZ_CP009922.3 | Streptomyces xiamenensis |
| 123 | 4162782 | 4163045 | - | NZ_CP023690.1 | Streptomyces spectabilis |
| 124 | 2319068 | 2319331 | - | NZ_CP029188.1 | Streptomyces tirandamycinicus |
| 125 | 1050201 | 1050455 | + | NZ_CP011502.1 | Aeromicrobium erythreum |
| 126 | 3035018 | 3035281 | - | NZ_CP013738.1 | Streptomyces globisporus C-1027 |
| 127 | 5269039 | 5269302 | + | NC_010572.1 | Streptomyces griseus subsp. griseus NBRC 13350 |
| 128 | 2893417 | 2893680 | - | NZ_CP070242.1 | Streptomyces californicus |
| 129 | 4728122 | 4728385 | + | NZ_CP023702.1 | Streptomyces nitrosporeus |
| 130 | 5247307 | 5247570 | + | NZ_CP011340.1 | Streptomyces pristinaespiralis |
| 131 | 1256759 | 1257010 | - | NZ_CP011340.1 | Streptomyces pristinaespiralis |
| 132 | 1578067 | 1578312 | - | NZ_CP017248.1 | Streptomyces fodineus |
| 133 | 6445227 | 6445472 | + | NZ_CP021080.1 | Streptomyces pluripotens |
| 134 | 3059907 | 3060161 | - | NZ_CP023693.1 | Streptomyces cinereoruber |
| 135 | 6331198 | 6331455 | + | NZ_CP023693.1 | Streptomyces cinereoruber |
| 136 | 2328687 | 2328956 | - | NZ_CP013290.1 | Janibacter indicus |
| 137 | 2015215 | 2015478 | - | NZ_CP029254.1 | Streptomyces spongiicola |
| 138 | 6518332 | 6518592 | + | NZ_CP029254.1 | Streptomyces spongiicola |
| 139 | 2904262 | 2904516 | - | NZ_CP029196.1 | Streptomyces venezuelae |
| 140 | 6627210 | 6627467 | + | NZ_CP029196.1 | Streptomyces venezuelae |
| 141 | 3357293 | 3357547 | - | NZ_CP010407.1 | Streptomyces vietnamensis |
| 142 | 6967127 | 6967384 | + | NZ_CP010407.1 | Streptomyces vietnamensis |
| 143 | 3675955 | 3676218 | - | NZ_CP027306.1 | Streptomyces atratus |
| 144 | 3586384 | 3586638 | - | NZ_CP059991.1 | Streptomyces gardneri |
| 145 | 1647196 | 1647444 | - | NZ_CP032427.1 | Streptomyces griseorubiginosus |
| 146 | 7408317 | 7408580 | - | NZ_CP051486.1 | Streptomyces pratensis |
| 147 | 7039045 | 7039266 | + | NZ_CP063374.1 | Streptomyces chromofuscus |
| 148 | 6834447 | 6834695 | + | NZ_CP010849.1 | Streptomyces cyaneogriseus subsp. noncyanogenus |
| 149 | 2164168 | 2164431 | - | NC_016111.1 | Streptomyces cattleya NRRL 8057 = DSM 46488 |
| 150 | 1688118 | 1688420 | - | NZ_CP012117.1 | Dermabacter vaginalis |
| 151 | 10068400 | 10068627 | - | NZ_CP034550.1 | Saccharothrix syringae |
| 152 | 2095513 | 2095758 | - | NZ_CP030073.1 | Streptomyces cadmiisoli |
| 153 | 4648795 | 4649046 | - | NC_013510.1 | Thermomonospora curvata DSM 43183 |
| 154 | 1382182 | 1382430 | - | NZ_LN831790.1 | Streptomyces leeuwenhoekii |
| 155 | 2669705 | 2669959 | - | NZ_CP026952.1 | Aeromicrobium chenweiae |
| 156 | 2289723 | 2289956 | + | NZ_CP068168.1 | Corynebacterium amycolatum |
| 157 | 642974 | 643252 | + | NZ_CP011541.1 | Corynebacterium epidermidicanis |
| 158 | 3224492 | 3224773 | + | NZ_CP047156.1 | Epidermidibacterium keratini |
| 159 | 5560810 | 5561034 | - | NZ_CP022753.1 | Nocardiopsis gilva YIM 90087 |
| 160 | 2720358 | 2720615 | + | NZ_CP038436.1 | Nocardioides seonyuensis |
| 161 | 835098 | 835331 | - | NZ_AP019307.1 | Nocardioides baekrokdamisoli |
| 162 | 2070336 | 2070626 | + | NZ_LT906443.1 | Corynebacterium ulcerans |
| 163 | 1774690 | 1774944 | - | NZ_CP060789.1 | Tessaracoccus defluvii |
| 164 | 652821 | 653084 | + | NZ_CP006841.1 | Corynebacterium lactis RW2-5 |
| 165 | 2776995 | 2777252 | + | NZ_CP019607.1 | Tessaracoccus flavescens |
| 166 | 1837139 | 1837360 | - | NZ_LT906473.1 | Corynebacterium cystitidis |
| 167 | 1142101 | 1142352 | + | NZ_CP038267.1 | Nocardioides euryhalodurans |
| 168 | 675847 | 676080 | + | NZ_LT906467.1 | Corynebacterium imitans |
| 169 | 845402 | 845620 | + | NZ_CP017812.1 | Boudabousia tangfeifanii |
| 170 | 348757 | 348990 | + | NC_022198.1 | Corynebacterium argentoratense DSM 44202 |
| 171 | 1460326 | 1460586 | - | NZ_CP032788.1 | Corynebacterium xerosis |
| 172 | 5107554 | 5107808 | - | NZ_AP022574.1 | Mycolicibacterium psychrotolerans |
| 173 | 2589740 | 2589994 | + | NZ_CP035494.1 | Microbacterium protaetiae |
| 174 | 3601350 | 3601604 | + | NZ_AP022600.1 | Mycolicibacterium tokaiense |
| 175 | 4042436 | 4042726 | - | NZ_CP045929.1 | Saccharopolyspora coralli |
| 176 | 2759163 | 2759420 | + | NZ_CP043474.1 | Mycobacterium grossiae |
| 177 | 1967636 | 1967893 | - | NZ_CP035495.1 | Xylanimonas allomyrinae |
| 178 | 1474950 | 1475219 | + | NZ_LT906453.1 | Dermatophilus congolensis |
| 179 | 868648 | 868872 | + | NZ_CP006712.1 | Bifidobacterium breve JCM 7017 |
| 180 | 1441569 | 1441832 | + | NZ_CP009312.1 | Lawsonella clevelandensis |
| 181 | 158999 | 159289 | - | NC_009806.1 | Kineococcus radiotolerans SRS30216 = ATCC BAA-149 |
| 182 | 1034933 | 1035208 | + | NC_013521.1 | Sanguibacter keddieii DSM 10542 |
| 183 | 3603161 | 3603427 | - | NZ_CP036250.1 | Egicoccus halophilus |
| 184 | 823818 | 824120 | + | NZ_LR131272.1 | Arthrobacter agilis |
| 185 | 1660253 | 1660522 | - | NZ_CP030033.1 | Cryobacterium soli |
| 186 | 1007140 | 1007361 | - | NZ_CP006018.1 | Bifidobacterium indicum LMG 11587 = DSM 20214 |
| 187 | 1026911 | 1027132 | - | NZ_CP007287.1 | Bifidobacterium coryneforme |
| 188 | 1896490 | 1896786 | - | NZ_CP061538.1 | Rothia amarae |
++ More..
| Neighborhood Conservation Analysis |
* Arrows marked in Genome Diagram shows ORFs; Multiple PFAMs can be mapped to a single ORF.
* 'Small ORF' represents the entry/query analyzed.
* Image generated using 'gggenes'(R-Package).
Neighborhood Representative Chosen(Species): NC_000962.3
| Sr.No. | Domain | Co-occurrence Frequency | No. of species in which domain occurs with smORF | Median distance b/w smORF and domain bearing ORFs | Orientation relative to smORF | PFAM Information |
|---|---|---|---|---|---|---|
| 1 | PF02878.18 | 0.78 | 139 | 1225 | same-strand | Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I |
| 2 | PF02880.18 | 0.78 | 139 | 1225 | same-strand | Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III |
| 3 | PF02879.18 | 0.78 | 139 | 1225 | same-strand | Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II |
| 4 | PF00408.22 | 0.76 | 136 | 1227.0 | same-strand | Phosphoglucomutase/phosphomannomutase, C-terminal domain |
| 5 | PF12005.10 | 0.73 | 130 | 706.0 | same-strand | Protein of unknown function (DUF3499) |
| 6 | PF01933.20 | 0.78 | 138 | 468.0 | opposite-strand | 2-phospho-L-lactate transferase CofD |
| 7 | PF00881.26 | 0.78 | 138 | 1472.0 | opposite-strand | Nitroreductase family |
| 8 | PF00483.25 | 0.63 | 112 | 4225.5 | same-strand | Nucleotidyl transferase |
++ More..